ID A0A097EE08_9SPHN Unreviewed; 1140 AA.
AC A0A097EE08;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=MC45_04690 {ECO:0000313|EMBL:AIT05818.1};
OS Sphingomonas taxi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1549858 {ECO:0000313|EMBL:AIT05818.1, ECO:0000313|Proteomes:UP000033200};
RN [1] {ECO:0000313|EMBL:AIT05818.1, ECO:0000313|Proteomes:UP000033200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55669 {ECO:0000313|EMBL:AIT05818.1,
RC ECO:0000313|Proteomes:UP000033200};
RA Zhou Y., Ma T., Liu T.;
RT "Using Illumina technology Improving SMRT sequencing Genome Assembly by
RT RASTools.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP009571; AIT05818.1; -; Genomic_DNA.
DR RefSeq; WP_038660149.1; NZ_CP009571.1.
DR AlphaFoldDB; A0A097EE08; -.
DR STRING; 1549858.MC45_04690; -.
DR KEGG; stax:MC45_04690; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_0_0_5; -.
DR Proteomes; UP000033200; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000033200}.
FT DOMAIN 9..496
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 519..786
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 938..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1140 AA; 122339 MW; E882C420494051B8 CRC64;
MAGTDLATLP RLKGAQAAAS DPHAHVWLSA SAGTGKTQVL AARVFRLLLG GTQPAAILCL
TFTKAGAAEM AQRISNRLAA WVRMPGPQLA ADLEALGERA TPDLQARART LFAGVLDAPG
GGLRIQTIHG FCQSLLAAFP VEAGLTPGFR PLEAREEAVL ARETLAALLV EAERDGRVRP
IETIGALSLR LGEGGAESFL LACARSLIAL EALPSGIQPW LRRTLDLPQG DIGEALASGC
DAIDVDLVER LAAANKAWGA ATGLGHAETL DRWLAAAPEA RAATLQELAG VVLTGKNEPR
KASKKLVDAE PDYPELAAAL GDHCLDLLSL TQRAAYADLL ADALDVGRDY ARAYAAAKRR
SGAVDFDDLI GVTVRLLEQP GIGEWVRYKL DQATEHVLID EAQDTNLNQW RIVTALAGEF
FVGRGVHAPS TRTLFTVGDF KQAIFGFQGT DPINFRWAEG HFATRAAEVE GAEDWPESER
GLPFQRLSLT HSFRSTRPIL EFVDAAVAAA GEPGLGAIGA LEDHASEVPG PGTVELWPPV
VAGGSDEDEE AWIDDAVREQ AVWIARAVRD WIDGGLMLES KGRPLRPEDV MILVKRRGDL
ASLIVARLYA EGVPVAGVDR LRLNSPLAVQ DLLAAVRFAL QPEDDLSLAS LLVSPLIGWT
QDELMHAAPR DHGSLWRHLT LTQSDERLAP LRSMLLRADI ATPYQFLEEL LSGPLDGRRK
LLRRLGAEAR DPIEELLNAA LAFETTSTPS MQRFLDWFDR GDVEIVRDPS APLDAVRVMT
AHGAKGLQAP LVILADATVD PTAAPRALVR WSPEPGAQPI PIFRPRSAER GGPLDVAIGE
VERRELEEHW RLFYVAATRA EERLVIGGAL GPRAKGEPPV ASWYAAASRA FDALGVAGEG
PRVFTGRVAQ PPVKTRPAAK AQRVEMVVLP EWAQRPAPIE SRPSRPLAPS AIGEDEVSDP
PPGPALRAAA ERGRLFHALF ERLPAVAPDA RAASAERWLA TAGGVTDPAV RAEIAAGVLA
VLDDARFADL FGGDALTEAP IAATLPNGLV VSGTVDRLLI APDHIRVVDF KTGRRVPDAV
ADIPLYHLDQ MAAYAAALAT IFPERRIEAA LLYTSGPRLF ALEPALLDAH KPRFRLREQS
//
