ID A0A097R021_HAFAL Unreviewed; 344 AA.
AC A0A097R021;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA polymerase III subunit delta {ECO:0000256|ARBA:ARBA00017703};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=holA {ECO:0000313|EMBL:AIU72086.1};
GN ORFNames=AT03_06540 {ECO:0000313|EMBL:AIU72086.1};
OS Hafnia alvei FB1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Hafnia.
OX NCBI_TaxID=1453496 {ECO:0000313|EMBL:AIU72086.1, ECO:0000313|Proteomes:UP000029986};
RN [1] {ECO:0000313|EMBL:AIU72086.1, ECO:0000313|Proteomes:UP000029986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FB1 {ECO:0000313|EMBL:AIU72086.1,
RC ECO:0000313|Proteomes:UP000029986};
RX PubMed=25075225; DOI=10.1186/1757-4749-6-29;
RA Tan J.Y., Yin W.F., Chan K.G.;
RT "Gene clusters of Hafnia alvei strain FB1 important in survival and
RT pathogenesis: a draft genome perspective.";
RL Gut Pathog. 6:29-29(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase HolA subunit family.
CC {ECO:0000256|ARBA:ARBA00034754}.
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DR EMBL; CP009706; AIU72086.1; -; Genomic_DNA.
DR RefSeq; WP_025800652.1; NZ_CP009706.1.
DR AlphaFoldDB; A0A097R021; -.
DR KEGG; hav:AT03_06540; -.
DR PATRIC; fig|1453496.5.peg.1312; -.
DR eggNOG; COG1466; Bacteria.
DR HOGENOM; CLU_044694_0_2_6; -.
DR OrthoDB; 9770982at2; -.
DR Proteomes; UP000029986; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18138; HLD_clamp_pol_III_delta; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR032780; DNA_pol3_delt_C.
DR InterPro; IPR010372; DNA_pol3_delta_N.
DR InterPro; IPR005790; DNA_polIII_delta.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01128; holA; 1.
DR PANTHER; PTHR34388; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR PANTHER; PTHR34388:SF1; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR Pfam; PF14840; DNA_pol3_delt_C; 1.
DR Pfam; PF06144; DNA_pol3_delta; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029986}.
FT DOMAIN 21..190
FT /note="DNA polymerase III delta N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06144"
FT DOMAIN 214..337
FT /note="DNA polymerase III subunit delta C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14840"
SQ SEQUENCE 344 AA; 39075 MW; 2A9197E3FE15B178 CRC64;
MTRVYPEQLA AQLREGLRAC YLVMGNEPLL LQESLDLIRQ QAQEHGFTEY FTFALDAHTD
WESIFSLSQA MSLFASRQII SLTLPENGAN AAIGEQLTKL STLLHPDLLL IIRGNKPTKA
QENAGWFKTL SQNAVMISCQ TPEQAQLPRW VATRAKQMNL QLDEAANQLI CYCYEGNLLA
LSQALERLSL LYPDGKLTLP RVEEAVSDAA HFSPFHWVDA ILAGRSKRAW HILQQLRQED
MEPVILLRTV QREVLLLMTL KSQMSHTPLR NLFDQHKVWQ NRRPAMTQAL QLLSLQQLHQ
SIALLSHIEV ILKQDYGQSV WSELESLTLL LCGKSLPESM LNAE
//
