ID A0A097R1Q5_HAFAL Unreviewed; 109 AA.
AC A0A097R1Q5;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Spermidine export protein MdtI {ECO:0000256|ARBA:ARBA00021114, ECO:0000256|HAMAP-Rule:MF_01597};
GN Name=mdtI {ECO:0000256|HAMAP-Rule:MF_01597};
GN ORFNames=AT03_09845 {ECO:0000313|EMBL:AIU72655.1};
OS Hafnia alvei FB1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Hafnia.
OX NCBI_TaxID=1453496 {ECO:0000313|EMBL:AIU72655.1, ECO:0000313|Proteomes:UP000029986};
RN [1] {ECO:0000313|EMBL:AIU72655.1, ECO:0000313|Proteomes:UP000029986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FB1 {ECO:0000313|EMBL:AIU72655.1,
RC ECO:0000313|Proteomes:UP000029986};
RX PubMed=25075225; DOI=10.1186/1757-4749-6-29;
RA Tan J.Y., Yin W.F., Chan K.G.;
RT "Gene clusters of Hafnia alvei strain FB1 important in survival and
RT pathogenesis: a draft genome perspective.";
RL Gut Pathog. 6:29-29(2014).
CC -!- FUNCTION: Catalyzes the excretion of spermidine. {ECO:0000256|HAMAP-
CC Rule:MF_01597}.
CC -!- SUBUNIT: Forms a complex with MdtJ. {ECO:0000256|ARBA:ARBA00011359,
CC ECO:0000256|HAMAP-Rule:MF_01597}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Cell membrane {ECO:0000256|HAMAP-
CC Rule:MF_01597}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01597}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01597}.
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DR EMBL; CP009706; AIU72655.1; -; Genomic_DNA.
DR RefSeq; WP_025801956.1; NZ_CP009706.1.
DR AlphaFoldDB; A0A097R1Q5; -.
DR GeneID; 78449856; -.
DR KEGG; hav:AT03_09845; -.
DR PATRIC; fig|1453496.5.peg.1977; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_133067_0_4_6; -.
DR OrthoDB; 71834at2; -.
DR Proteomes; UP000029986; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015606; F:spermidine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 1.10.3730.20; -; 1.
DR HAMAP; MF_01597; MdtI; 1.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR InterPro; IPR023737; Spermidine_export_MdtI.
DR PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR PANTHER; PTHR30561:SF6; SPERMIDINE EXPORT PROTEIN MDTI; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01597};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01597};
KW Reference proteome {ECO:0000313|Proteomes:UP000029986};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01597};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01597};
KW Transport {ECO:0000256|HAMAP-Rule:MF_01597}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
FT TRANSMEM 91..108
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01597"
SQ SEQUENCE 109 AA; 11910 MW; 42208F1DE5340E4B CRC64;
MQQLEWFHIA WLAFAVVLEI LANIFLKWSD GFRRIWMGLL SLAAVLGAFS SLSQAVKGIE
LSVAYALWGG FGIAATVAAG WILFGQRLNK KGWAGLTLLL AGMIMIKLA
//
