ID A0A097R3W8_HAFAL Unreviewed; 740 AA.
AC A0A097R3W8;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Mechanosensitive channel protein {ECO:0000313|EMBL:AIU73410.1};
GN ORFNames=AT03_14105 {ECO:0000313|EMBL:AIU73410.1};
OS Hafnia alvei FB1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Hafnia.
OX NCBI_TaxID=1453496 {ECO:0000313|EMBL:AIU73410.1, ECO:0000313|Proteomes:UP000029986};
RN [1] {ECO:0000313|EMBL:AIU73410.1, ECO:0000313|Proteomes:UP000029986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FB1 {ECO:0000313|EMBL:AIU73410.1,
RC ECO:0000313|Proteomes:UP000029986};
RX PubMed=25075225; DOI=10.1186/1757-4749-6-29;
RA Tan J.Y., Yin W.F., Chan K.G.;
RT "Gene clusters of Hafnia alvei strain FB1 important in survival and
RT pathogenesis: a draft genome perspective.";
RL Gut Pathog. 6:29-29(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP009706; AIU73410.1; -; Genomic_DNA.
DR RefSeq; WP_025798120.1; NZ_CP009706.1.
DR AlphaFoldDB; A0A097R3W8; -.
DR KEGG; hav:AT03_14105; -.
DR PATRIC; fig|1453496.5.peg.2877; -.
DR eggNOG; COG0668; Bacteria.
DR HOGENOM; CLU_013626_2_0_6; -.
DR OrthoDB; 6500477at2; -.
DR Proteomes; UP000029986; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029986};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..740
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001937224"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..552
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 553..618
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 628..710
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
SQ SEQUENCE 740 AA; 82177 MW; 048A47AEF07E00F5 CRC64;
MPQGARLIPF FTRYFVLLTV LFFSCSASVN AVEPQKETDS KAAYSALADI LSDASSRDAL
IAELRDSAKT GKPLAEKSAS TVPAEPRDET FADQLDSSIQ GYLTVAQSKL DRLIMALKSP
PHKAFNPQTF WPALTHFLFT VAVTFALFLA IRFFATPFYK RIGSWGHKAR EKRADWARRP
TAIISAFVID LLILLFCVTA GNIIATAFGT NSPVTMRQQA LFLNAFALIE FFKAILRLIF
APKFDYLRPF PFSDATAKYW NTRLAWLSGL IGYGLMVVVP IIQVQLGASS AVLVNFCIML
ALTVYAIGLI LVNRLRIQKE IAALGNRSLA FFGVFLHALS HIWHILAIVY FLVLFLLSQF
DPGNSLAFMM NATIKSLIVV GSGALISGLL TRWISRRIAL PADIKLKYPM LERRVNSYIP
SALQIMRFIV VVAILLFLLD AWHIFGLRAW LDSATGEKII GGLVHILLIM FIAVLGWTLL
ASVIEHRLSL EMDNPKHPGA RERTLLTLFR NVLSIVITTI TVMIILSQIG INIAPLLAGA
GALTLAVSFG AQTLVKDVIN GIFIQFENGM NTGEYVTVFG ITGTVERMTI RSIGLRDDYG
VYHLVPYSSI TTVANYAREF GVYRANYVIS RDEDIEKANE VLKQAVAELR DNPRLKSLLI
GEPAFNGVVK LDDVSFTLRT TIRTVALQQW TIQYALDKLV KEHFQRAGIK TPHQNVQISY
AAPEQQALLP PQNGPDSIEK
//
