ID A0A098ETS8_9BACI Unreviewed; 542 AA.
AC A0A098ETS8;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BN1002_00104 {ECO:0000313|EMBL:CEG25311.1};
OS Bacillus sp. B-jedd.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1476857 {ECO:0000313|EMBL:CEG25311.1, ECO:0000313|Proteomes:UP000042335};
RN [1] {ECO:0000313|EMBL:CEG25311.1, ECO:0000313|Proteomes:UP000042335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-jedd {ECO:0000313|EMBL:CEG25311.1,
RC ECO:0000313|Proteomes:UP000042335};
RA Urmite Genomes Urmite Genomes;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CCXR01000001; CEG25311.1; -; Genomic_DNA.
DR RefSeq; WP_048823069.1; NZ_CCXR01000001.1.
DR AlphaFoldDB; A0A098ETS8; -.
DR STRING; 1476857.BN1002_00104; -.
DR OrthoDB; 9815272at2; -.
DR Proteomes; UP000042335; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CEG25311.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000042335};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3..295
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 542 AA; 63433 MW; 4FD755CA34FF2E23 CRC64;
MSDKKENGAY YTPGYLAEYI VNEIFSEYSF YKNKMKMLEP SSGDGIFIKS LLKSTLIPQD
VTLQIDVVEK NKEELEKVKL HKLTRDNSEL NYFATDFLNY NSSGNKYDLI IGNPPYINKK
LLSEEQIDSS ISIFSEHQLN PRGFNNIWMS FILKSMFMLE QNGTLCFVLP SELLQVNYSS
ELRRYLFDNF SEIKIFLFNE LVFEKIQQDV IIFIASKKGV SKSVNYYEID DLSVIRNKVK
LIPYSIVDYN SQKKWSNYLL SRSELKLIDT VANSFNKVSD YCTATAGIVT AANDYFIVNK
QNQLKYNLSD ISFPILKKSS YLEKGINLTV DHITSLEKRG HPIYLLIFNK KNIHDYQGQL
RKYLEVGLKK EIHLRYKSKN RFPWFKVPYL EAPEGIFFKR SHLYPKIIVN SANVLTTDNG
YRITMKEGYR IHSLVFSFYN SFTLLMSELE GRYYGGGVLE LTPNEFKRLP LPYCEIGEEE
FTHLDNLFKE GRSIEEILDY TDNIILMQHY GVGNDELIYI RNLRNKLMRR RLKEINHVLQ
AL
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