ID   A0A098GBW4_9GAMM        Unreviewed;       656 AA.
AC   A0A098GBW4;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:CEG58976.1};
DE            EC=5.4.99.17 {ECO:0000313|EMBL:CEG58976.1};
GN   Name=shc {ECO:0000313|EMBL:CEG58976.1};
GN   ORFNames=LFA_3651 {ECO:0000313|EMBL:CEG58976.1};
OS   Legionella fallonii LLAP-10.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=1212491 {ECO:0000313|EMBL:CEG58976.1, ECO:0000313|Proteomes:UP000032430};
RN   [1] {ECO:0000313|Proteomes:UP000032430}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC700992 {ECO:0000313|Proteomes:UP000032430};
RA   Gomez-Valero L.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
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DR   EMBL; LN614827; CEG58976.1; -; Genomic_DNA.
DR   RefSeq; WP_045097189.1; NZ_LN614827.1.
DR   AlphaFoldDB; A0A098GBW4; -.
DR   STRING; 1212491.LFA_3651; -.
DR   KEGG; lfa:LFA_3651; -.
DR   HOGENOM; CLU_019345_0_0_6; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000032430; Chromosome.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0051007; F:squalene-hopene cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:CEG58976.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032430};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          13..297
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          306..603
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   656 AA;  73765 MW;  813B9D7CA85280C0 CRC64;
     MIEPKRNILD IVIKRATDYA LGIQHQEGYW IAPLDSNSTM EAEFLLLLYF LGIHDEVRQQ
     KIVNHILKHQ QEDGSWSLYF QGSGDLSTTV ECYFALMLSG VSKDAPNMKL AREFIIAKGG
     IAKVRVFTQI WLALFGQWSW QQIPTLLPEI IFLPSWFPFN VYAFASWARA TVVPLTIVMA
     ERPVCAIPNH CALTDLFLQD AMPQKAQGHG IWGVIFKVIE KGFKLYERMP WKPGRRLAIK
     KSIQWIIDHQ EADGSWGGIQ PPWVYSLIAL KLTGHSLEHP VMRKGIDGFD SFSIEDNETM
     QVQACVSPVW DTSLMINALK EVGVESSHPQ IQSACRWLIK KQILVGGDWS IQNPKLSPGG
     WAFEFENANY PDIDDTAEVL MALWHASLSE SENVQCKVAI KTGTQWLLGM QGKNGGWAAF
     DRENNNFFLA KFPFFDFGEI LDPPSVDVTA HVLEALGMMG YTRDNPVIKR ALDYIYQEQE
     PNGSWFGRWG VNYIYGIGTV LPALRAVGED ITSPTIQKAI QWLLAHQNAD GGWGESCASY
     VDVTQHGCGP STPSQTAWAL LALMAVDQYE HPAVHKGIDY LCDTMNVQGT WDEDHYTGCG
     FPGYGEGQRK SIASLQEGHL KDAIASAGFM INYNLYRHCW PLMALGRYQK GWFGNK
//