ID A0A098VM40_9MICR Unreviewed; 3501 AA.
AC A0A098VM40;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Midasin {ECO:0000313|EMBL:KGG50167.1};
DE Flags: Fragment;
GN ORFNames=DI09_84p60 {ECO:0000313|EMBL:KGG50167.1};
OS Mitosporidium daphniae.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Mitosporidium.
OX NCBI_TaxID=1485682 {ECO:0000313|EMBL:KGG50167.1, ECO:0000313|Proteomes:UP000029725};
RN [1] {ECO:0000313|EMBL:KGG50167.1, ECO:0000313|Proteomes:UP000029725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGP3 {ECO:0000313|EMBL:KGG50167.1,
RC ECO:0000313|Proteomes:UP000029725};
RC TISSUE=Spores {ECO:0000313|EMBL:KGG50167.1};
RA Haag K.L., James T.Y., Larsson R., Schaer T.M., Refardt D., Pombert J.-F.,
RA Ebert D.;
RT "A new species of microsporidia sheds light on the evolution of extreme
RT parasitism.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
CC {ECO:0000256|ARBA:ARBA00009028, ECO:0000256|RuleBase:RU003447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGG50167.1}.
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DR EMBL; JMKJ01000595; KGG50167.1; -; Genomic_DNA.
DR RefSeq; XP_013236603.1; XM_013381149.1.
DR GeneID; 25260952; -.
DR VEuPathDB; MicrosporidiaDB:DI09_84p60; -.
DR HOGENOM; CLU_224810_0_0_1; -.
DR OrthoDB; 169704at2759; -.
DR Proteomes; UP000029725; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR003701; Mre11.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR NCBIfam; TIGR00583; mre11; 1.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 5.
DR Pfam; PF17867; AAA_lid_7; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR SMART; SM00382; AAA; 5.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003447};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003447};
KW Endonuclease {ECO:0000256|RuleBase:RU003447};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|RuleBase:RU003447};
KW Hydrolase {ECO:0000256|RuleBase:RU003447};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU003447};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|RuleBase:RU003447};
KW Nuclease {ECO:0000256|RuleBase:RU003447};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003447};
KW Reference proteome {ECO:0000313|Proteomes:UP000029725}.
FT DOMAIN 269..440
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT DOMAIN 512..627
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 818..1071
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1266..1460
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1624..1797
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2038..2187
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1340..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 3501
FT /evidence="ECO:0000313|EMBL:KGG50167.1"
SQ SEQUENCE 3501 AA; 389598 MW; B53CB31B22083930 CRC64;
MEKDPIRGED SFLAFQEILE TAKARNVDMI LLGGDLFHEN KPSRKAIYQT IELLRQYTFG
DGESYLEFLS DPSINFPHTK FPNANYLDEN LNVSIPVFII HGNHDDPSGD SNLSAVDILS
VGGLVNYFGK VKDVDDIVAS PVLLAKGNTR LALYGIGSIR DERLYRSFQR NKVKFLRPLE
DEESWFSLLT FHQNRSAHGP TNYIPEAFLD PMFDFILWGH EHECLIDPQL NPQKEFYVCQ
PGSSVATSLC EGESKEKFFG LLSITGKSFE LEKIKLKNIR PFVMKEISLS SISNLPLMDI
KKINKTLVDQ VNLLIAQATL AKSIEETPER LRLPLIRLKV AMIIHQILTL VRFGQQFVDV
IANPKDLVTF FRKRAAASAY RKRRSTIEFE EDAQSEAHSS ECLVNQQELA NVESLLMEAL
QGHSLQILPE LEMASALKSF VDKDEKDAIE NTVFKALEKI ASTIVDSVTS LDTESVRVEV
FCNILMLPSY PKVHSSERDV EASITIRESI QIQVPVIVQG PIGCGKTHLI QRLATEYDAT
LTVLGVSGDA GDLKLLLGTF ITGPNNSFIW KRGLLTLAVE EGHWVLFKDI SHQSSTEIIA
MLATLLQERI LVIPSRSERI VAHSSFRLFI TQTDGHILYP GLNCLVSLPP RTASETISIM
SYMLLSIPNS TNLTSGQCKQ ISEFVYTAAS LNKERVSSMS DLVKAINRLL PHLVAGNGNE
EHGLSLDLRQ KILEISIDLF ALSVTNYDER YSLQMAIARI LGLSQECDLK VILESELGSN
RDSYSLKGLE NHQSTQGNIA MMKQTKMLLN ALYRGVSSNE PMLLVGPTGT GKTTIVQYLS
ELEKPPGGLF VVNLHAQTEH SDLFGSWSQQ SSTTEIMKRA MDEFGFLFEA SGHKREANGT
LFSKLIRWAS CCHTDPKSIS SFWTQIATIS KLILSKMGHE TSHEKISPIS AEVCDRWNEL
IAMALRFSGS PCSATFVFAE GVILKALQTG AWLLLDEINL APPSLLLLLE SLVAGHPVRV
FERGDERPVF RHPSFRLFAC MNGVLSESTR RALPESLRAK FTEITIDPIE RFPEDVRLLV
DSRLKASMPT SFVPFPGFEL GPFFVSVYYR IRKGLADREL CGPEEPSWTI RSLCRLVDAW
QQFMSPPQSG SVLWALKQAI MVVVGGQLDS SSVKFLLCTI ISQLIDPQIT FLLSQSAVST
RKSCHVESGS MVSITGTDDG EYCLFLPKGP LEVEKLDACT GRFIETQVAH KCMLAIARVF
AASIKRPWAL MLVGPTSAGK TTAVAELARR TGHRLIRINN HEHTDVSEYL GAWGFSHVDD
EAKMTPMISE CTDGFHSSDL GQLSSSQASS SGSCVPKTES SSASNPIHIR FAYGALVRAM
LTGSWLLLDE LNLAPTEVLE SLNRLLDDNR ELYIPETGET IRPHPSFRLF ATLNPHGRGY
GGRHVLSEAF KSRWIILQVE EDPAVDDIIR GRSGGSQSSW LAPAISAKMA SVFMEIRKRR
RAGSILDSNS LITLRDMFRW AFRIKQLSDA DASRGAWLLA AQAGWSLLGE RLRTEVERRA
LQDLLIENFP MASSSPSPVD SRDWLFSDYG RWPGVPALGS FSRGIVWTGH FQRVGALAIA
AIRNREPLLL VGETGTGKTS IVQWLAESQN LPLHTVACHQ YTDVGDFLGM QRPCASIDSD
SNGKRHRGGM PSPSSWVWVD GPLVTAMREG HILLVDEISL AEDSVLERLN SVLESDNRML
TVVENFGGSS TEPMVIQAHP NFALIATMNP SGDFGKRELS PALRNRFTEV WVPSPASSIE
VLLLLHGICS EDVAEKSIPE FLSSELCNVK EIPKCILAFC SWFLSSLNRS NGQFLDLSTD
EALIASFSGF VTPAVTLSIR DLKTWIEFIK INARGLCPSK WSSASESLVS CKLSVGEAYC
QGAEMIFLDG LSMLANSGGV LPFAISPENI SSFRKTARTL LARHGALLSP MEEIPHRQKI
FSTREDHSAW GIAPFYVAIR SKKTHIAIES HPDVGAFSLS APTVIENAYR VFRAMQISHR
PILLEGDPGV GKTSLISAIA KRTGNESLVR INLSEQTDLS DLFGVDMPSG SLFSWRDGPL
LAGIKAGHWI LLDEINLASQ QVLEGLNSIL DHRGTIYVAE LNRSWKIDST SVRIFATQNS
RREGGGRKGL PQSFLNRFTR VYLEPLSEAD LVAIVKGEKD QSLPVITNAV KTAMRLNATF
SPQFDFNLRD VSRLLSLNPT NQFTLRRAEE LVFGARFDDM PGLDCGDAFD ATESNNYRLF
LSVRNELRLP LVARWLLQNR VGDAIEIALH KKWLVLLRSP DASAFPMSLS EIIHHFADTK
GAVLHSIPLT ALSETSDFLG GFEQQPDQEL GAGFHWKNGV LLDALEKGHW IFFENASACP
SSVLDRLNGL FEPNGSLFVH EKSGFGDPMI PHPNFRAFMG VSSCGSGSIS RPMRNRALEI
CVGNLPPPSI LDTMRFLWMR VRHKFGSDLE FYGFAKWLHA HAMTVYANDD SRSEYFKRLL
LQLRKSKCTD KYAVEEIPCS SLIIMQSLSM PACLENGGVC LFLQKFIKCI FDDNAMVRPI
LFEFHLAIEA LTVLYASGNN FPSERDIFSQ KLSLLSFKGS GSREKQDLSA MACRMMLFEK
FKAFHIPPCL GRFFNLVIHE GECSDSMAYF SLWRKWFSNP AFLARKNGLL WNSPLASPEH
VFPQNRYSER RLMLSSSALL AIYSAHEKPE HFCCGGNAES SETMECEPNH IFGCLNRFYG
TVALYAVAYK NVEVLDLILT IESLPRPVLY DLQYYLWSLV PSSPLYAIFQ KSQIPFMLAC
ILKLLKLLCG DISMSILEAA FDVYSLSSGA NTFVEMSGLS RTFTALGQFN DFFASAQFAC
FLKQIDNGEA PELICDVLSI DGKSTNVDML RGILHMLSEL CAPVVDPILF PVLSPIFAAQ
AHLNIEVDML VLQTFQLVCG SLNHPEAFDE QVKKVLFIST GLSDSIDAAL GESVPSVFDV
SVPYFCGIIS QFTIFKNELL SKLPSHIDDS SFAAIDLSNL HHFLLSLLSQ IEQVDIPFDI
VGSLLLPLIL LSLLKIIKPN RFSKCSSISA IGPLCSFGGS FSSPLLGKAY MDWAMSYSGA
SRSNLNILYS FLYAHNPCSE IINMKIADVY LPKDVFVLTQ TKMPPFILTP NTIYDMLFRI
SSAMVSLNDE LRNKIATSNI SDFIVSDFTA SISSLLLLNI DFCIVKTTSW NALYECITTV
SSKIMTCIET GYEVARLNDK TGFSSWLVTQ LDALSRLLIE FRKQEIALIC SMLLQEDTLY
FSDSLASFSL DQFVTLFRES LRSDIDFESL FKLLDAFVLN TSIVEARLRI ELLFALFHFH
ERNGAGRSNT ALLNVLWHGG SYFNAFYVRK IASHISKESA VLLSEIREKA TLISCSYLNE
MIVRQCSDKI HHLTSRSLKA LNEMLTTPTV SFISSCKACV VQVGWKFDLA CNILPADESI
KVLAKASRLF SAEMERLWRG V
//