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Database: UniProt
Entry: A0A098VVY5_9MICR
LinkDB: A0A098VVY5_9MICR
Original site: A0A098VVY5_9MICR 
ID   A0A098VVY5_9MICR        Unreviewed;       973 AA.
AC   A0A098VVY5;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   08-MAY-2019, entry version 27.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=DI09_10p140 {ECO:0000313|EMBL:KGG53117.1};
OS   Mitosporidium daphniae.
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Mitosporidium.
OX   NCBI_TaxID=1485682 {ECO:0000313|EMBL:KGG53117.1};
RN   [1] {ECO:0000313|EMBL:KGG53117.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UGP3 {ECO:0000313|EMBL:KGG53117.1};
RC   TISSUE=Spores {ECO:0000313|EMBL:KGG53117.1};
RA   Haag K.L., James T.Y., Larsson R., Schaer T.M., Refardt D.,
RA   Pombert J.-F., Ebert D.;
RT   "A new species of microsporidia sheds light on the evolution of
RT   extreme parasitism.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGG53117.1}.
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DR   EMBL; JMKJ01000011; KGG53117.1; -; Genomic_DNA.
DR   RefSeq; XP_013239544.1; XM_013384090.1.
DR   EnsemblFungi; KGG53117; KGG53117; DI09_10p140.
DR   GeneID; 25257968; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      103    323       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      387    825       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      888    952       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   COILED      508    532       {ECO:0000256|SAM:Coils}.
FT   COILED      952    972       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   973 AA;  110992 MW;  E2D56763F0E02DD8 CRC64;
     MHDEDEASYF VNEERYEEEC ASSTFDKGFM HIEIDFIMDS PLEEVASGFP GIGLVPIFRL
     FGVTEKEQSV LCHLHGFLPY FYVRTPSENF LPSHCQLFQE ALELTGMNWI EIDQKNYIVR
     TQKEHLTSLC QIEIDTTFDK IISFTPDGIH ATVPPLRILS FDIECAGRKG IFPEPHIDAV
     IQIGNVFSVH GEGMPRVSVI FTLNTCSQIA GAEVLSFANE ADMLAAWSQF VRTLDPDIIT
     GYNINNFDLN YLLDRAHTLR ETSFPFLGRI PALRTKSRDS IFSSKAYGTR ESKEISIDGR
     VILDMIQVIQ RDYKLRSYSL NSVCAHFLGE QKEDVHHSII TDLQNGNSET RRRLAVYCLK
     DALLPQRLID RLMSLVNYIE MARVTGIPFN FILQRGQQIR VISQLYRKAS EEGYVVPALR
     TEAGSDEQYE GATVIEPIKG YYDIPIATLD FASLYPSIMM AHNLCYTTLL DASSITKLNL
     SPSDYIRTPS GDYFVASHVR KGLLPQILED LLEARKRAKN DLKSENDRFR KAVLDGRQLA
     LKISANSVYG FTGATVGKLP CIQISQSTTS FGRQMIDLTK EAYTIENGYD ANAKVIYGDT
     DSVMINFGAP DLAKTMELGK LGSLLFLQGR HAANFVSSSF KYPIRLEFEK AYFPYLLINK
     KRYAGLYWSN PHSYDKIDAK GIETVRRDNC PLVQTLIQTC LNKILIDRDV EGAKQYAKQV
     ISDLLQNKID ISLLVITKAL TKSGESYAGK QAHVELAEKM RKRDAGSAPS LGDRVAYVIT
     KSTKGAAAYE KSEDPLYVLE HNIPIDTKYY LENQLSKPLL RIFEPVIKHA DELLGIVFLS
     FWHSRRPYKN HSCSGPHTWR IEEICCQDRV LSWMQGPACE RRLCRCLHLF VEKLVCKFCR
     PELPKFYLKH VDMLKQTEIK FNRLWTQCQR CQGSLHQDVL CTSKDCPIFY MRKKAQKEVK
     EVSDLMEKFE FDW
//
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