ID   A0A099D0S4_9ACTN        Unreviewed;       986 AA.
AC   A0A099D0S4;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Exonuclease SbcC {ECO:0000313|EMBL:ASU79860.1};
GN   ORFNames=CDG81_18110 {ECO:0000313|EMBL:ASU79860.1}, IL38_21940
GN   {ECO:0000313|EMBL:KGI79624.1};
OS   Actinopolyspora erythraea.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinopolysporales;
OC   Actinopolysporaceae; Actinopolyspora.
OX   NCBI_TaxID=414996 {ECO:0000313|EMBL:ASU79860.1, ECO:0000313|Proteomes:UP000215043};
RN   [1] {ECO:0000313|EMBL:KGI79624.1, ECO:0000313|Proteomes:UP000029737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM90600 {ECO:0000313|EMBL:KGI79624.1,
RC   ECO:0000313|Proteomes:UP000029737};
RX   PubMed=25250723;
RA   Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT   "Identification and Characterization of a New Erythromycin Biosynthetic
RT   Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-
RT   Producing Halophilic Actinomycete Isolated from Salt Field.";
RL   PLoS ONE 9:E108129-E108129(2014).
RN   [2] {ECO:0000313|EMBL:ASU79860.1, ECO:0000313|Proteomes:UP000215043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU79860.1,
RC   ECO:0000313|Proteomes:UP000215043};
RA   Yin M., Tang S.;
RT   "The complete genome sequence of moderately halophilic actinomycete
RT   Actinopolyspora erythraea YIM 90600, the producer of novel erythromycin,
RT   novel actinopolysporins A-C and tubercidin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP022752; ASU79860.1; -; Genomic_DNA.
DR   EMBL; JPMV01000041; KGI79624.1; -; Genomic_DNA.
DR   RefSeq; WP_043577850.1; NZ_KN214180.1.
DR   AlphaFoldDB; A0A099D0S4; -.
DR   KEGG; aey:CDG81_18110; -.
DR   eggNOG; COG0419; Bacteria.
DR   HOGENOM; CLU_004785_2_0_11; -.
DR   OrthoDB; 9795626at2; -.
DR   Proteomes; UP000029737; Unassembled WGS sequence.
DR   Proteomes; UP000215043; Chromosome.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   PANTHER; PTHR32114; ABC TRANSPORTER ABCH.3; 1.
DR   PANTHER; PTHR32114:SF2; ABC TRANSPORTER ABCH.3; 1.
DR   Pfam; PF13476; AAA_23; 1.
DR   Pfam; PF13558; SbcC_Walker_B; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Exonuclease {ECO:0000313|EMBL:ASU79860.1};
KW   Hydrolase {ECO:0000313|EMBL:ASU79860.1};
KW   Nuclease {ECO:0000313|EMBL:ASU79860.1}.
FT   DOMAIN          6..186
FT                   /note="Rad50/SbcC-type AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13476"
FT   REGION          95..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          249..336
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        95..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..549
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  110419 MW;  B71725FB3EFB1AAA CRC64;
     MRLHHLELSA FGPFRDRQRV DFDELGADGL FLLHGDTGAG KTTVLDAVTF ALYGHVPGAR
     DQAKALRCDT APPETPTWVE LELTVQGCRM RVRRNPEYER PKKTGSGTTR EKPKASLTWL
     NEPPAGEPPE GITRPNDVGP TVERLLGLDV RQFCHVALLP QGDFARFLRA DAKERADLLE
     KLFDTRQFSR IEQWFTELRR KRRDELDGAR QHGEKLLARF CQVAGEEPGE EQDRAEWLDG
     VERSFARQYE RARAEHERLS GQRQRADEAL AAQRELADRV SRVRAARAEL DELDSRAEEY
     RAAGAELDAA RRAKPVDNAA RELDSGVARL RAAERELHDA LADCPEAEPG EAEGTDTETL
     RARSSRYRET AAVLADRARE AEQQRRDRER IAELDQSLAA DLATDEDLAE QERRLPEAIE
     QALAAVREAE RAPERLEAVT SRCDELDTAL RAAGELPEAE ARRAAARERA HRAVDEHQAA
     REHLQDVRER RLAGMAAELA AQLGEGTACP VCGSSRHPEP AEPHDSSVGA EEERTAREAE
     AECQRRRDRE REYVAEAERE CARLREQLGD RAEHQLREEF DRLTAEREAL GELVEQQRAR
     ADRLAELRGR TEELGNRRAE LDRRVNAARS TRESLAETVA ERQQRLRAAR GEFDTVAARR
     DHLLELAQRL ERAVTARGEH DRASAHETER REALARVATE NGFQTPEAAL EARREQSRID
     ELAEWLRDVD RRDAAARATL RELPDVPPDT EVDVDGAAEA AERARRLAEE ATGVLGDLDR
     RSAQLAELGR ELRQSWKELE PAEREFAELH ALTDVINGQG QNARRMTLRS YVLAARLEEV
     AEAATARLRH MSDGRYAFVH SDEQGTHGKR GGLDLRVVDD YSGRTRSTRT LSGGESFLAS
     LSLALGLADV VSAEAGGAML DTLFIDEGFG TLDGDTLDLV MDALDELRAG GRMVGLVSHV
     DELRQRVPIR LRVRKSRGGS SLAIES
//