ID A0A099D0U2_9ACTN Unreviewed; 361 AA.
AC A0A099D0U2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Magnesium transport protein CorA {ECO:0000256|RuleBase:RU362010};
GN Name=corA {ECO:0000256|RuleBase:RU362010,
GN ECO:0000313|EMBL:ASU79753.1};
GN ORFNames=CDG81_17455 {ECO:0000313|EMBL:ASU79753.1}, IL38_22635
GN {ECO:0000313|EMBL:KGI79521.1};
OS Actinopolyspora erythraea.
OC Bacteria; Actinomycetota; Actinomycetes; Actinopolysporales;
OC Actinopolysporaceae; Actinopolyspora.
OX NCBI_TaxID=414996 {ECO:0000313|EMBL:ASU79753.1, ECO:0000313|Proteomes:UP000215043};
RN [1] {ECO:0000313|EMBL:KGI79521.1, ECO:0000313|Proteomes:UP000029737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM90600 {ECO:0000313|EMBL:KGI79521.1,
RC ECO:0000313|Proteomes:UP000029737};
RX PubMed=25250723;
RA Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT "Identification and Characterization of a New Erythromycin Biosynthetic
RT Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-
RT Producing Halophilic Actinomycete Isolated from Salt Field.";
RL PLoS ONE 9:E108129-E108129(2014).
RN [2] {ECO:0000313|EMBL:ASU79753.1, ECO:0000313|Proteomes:UP000215043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU79753.1,
RC ECO:0000313|Proteomes:UP000215043};
RA Yin M., Tang S.;
RT "The complete genome sequence of moderately halophilic actinomycete
RT Actinopolyspora erythraea YIM 90600, the producer of novel erythromycin,
RT novel actinopolysporins A-C and tubercidin.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates influx of magnesium ions.
CC {ECO:0000256|RuleBase:RU362010}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362010}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362010}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765, ECO:0000256|RuleBase:RU362010}.
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DR EMBL; CP022752; ASU79753.1; -; Genomic_DNA.
DR EMBL; JPMV01000043; KGI79521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099D0U2; -.
DR KEGG; aey:CDG81_17455; -.
DR eggNOG; COG0598; Bacteria.
DR HOGENOM; CLU_007127_0_2_11; -.
DR OrthoDB; 9803416at2; -.
DR Proteomes; UP000029737; Unassembled WGS sequence.
DR Proteomes; UP000215043; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd12830; MtCorA-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR004488; Mg/Co-transport_prot_CorA.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR NCBIfam; TIGR00383; corA; 1.
DR PANTHER; PTHR46494; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR PANTHER; PTHR46494:SF1; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU362010};
KW Ion transport {ECO:0000256|RuleBase:RU362010};
KW Magnesium {ECO:0000256|RuleBase:RU362010};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362010};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362010}; Transport {ECO:0000256|RuleBase:RU362010}.
FT TRANSMEM 304..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362010"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362010"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 40699 MW; 3A6F47AE47E2FCF5 CRC64;
MPSLPNLGLR NRVNRGDRGS RSAPSSGVRS ASVVDCAVYV EGKRLPGEWS HEEAMAEVRS
RRGGFVWIGL HEPDQERING IAETFGLHEL AVEDAVHAHQ RPKLEHYDDT LFMVLKTVRY
VPDRARATNS EIVSSGELMI FLGRDFVITV RHGNQAALTR VRAELERSPE QLALGPSAVL
HGISDHVVDS YLEVTESIQD DIDSIETEVF APRTSIDAEQ IYLMKREVMQ LRRAVMPLSQ
PLQRLAGDHT PHVADQVRSY FRDVEDHLAT VSERVASFDE LLTTLVDATL AKITLQQNTD
MRKISAWVAI ISTPTMIAGV YGMNFDRMPE TEWAFGYPVT LLVMMVCCVM LFKIFRRNNW
L
//
