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Database: UniProt
Entry: A0A099D656_9ACTN
LinkDB: A0A099D656_9ACTN
Original site: A0A099D656_9ACTN 
ID   A0A099D656_9ACTN        Unreviewed;       289 AA.
AC   A0A099D656;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:KGI81484.1};
DE   SubName: Full=NAD(P)-dependent oxidoreductase {ECO:0000313|EMBL:ASU78729.1};
GN   ORFNames=CDG81_11085 {ECO:0000313|EMBL:ASU78729.1}, IL38_11140
GN   {ECO:0000313|EMBL:KGI81484.1};
OS   Actinopolyspora erythraea.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinopolysporales;
OC   Actinopolysporaceae; Actinopolyspora.
OX   NCBI_TaxID=414996 {ECO:0000313|EMBL:ASU78729.1, ECO:0000313|Proteomes:UP000215043};
RN   [1] {ECO:0000313|EMBL:KGI81484.1, ECO:0000313|Proteomes:UP000029737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM90600 {ECO:0000313|EMBL:KGI81484.1,
RC   ECO:0000313|Proteomes:UP000029737};
RX   PubMed=25250723;
RA   Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT   "Identification and Characterization of a New Erythromycin Biosynthetic
RT   Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-
RT   Producing Halophilic Actinomycete Isolated from Salt Field.";
RL   PLoS ONE 9:E108129-E108129(2014).
RN   [2] {ECO:0000313|EMBL:ASU78729.1, ECO:0000313|Proteomes:UP000215043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU78729.1,
RC   ECO:0000313|Proteomes:UP000215043};
RA   Yin M., Tang S.;
RT   "The complete genome sequence of moderately halophilic actinomycete
RT   Actinopolyspora erythraea YIM 90600, the producer of novel erythromycin,
RT   novel actinopolysporins A-C and tubercidin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
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DR   EMBL; CP022752; ASU78729.1; -; Genomic_DNA.
DR   EMBL; JPMV01000018; KGI81484.1; -; Genomic_DNA.
DR   RefSeq; WP_043573154.1; NZ_KN214176.1.
DR   AlphaFoldDB; A0A099D656; -.
DR   KEGG; aey:CDG81_11085; -.
DR   eggNOG; COG2084; Bacteria.
DR   HOGENOM; CLU_035117_0_4_11; -.
DR   OrthoDB; 3185659at2; -.
DR   Proteomes; UP000029737; Unassembled WGS sequence.
DR   Proteomes; UP000215043; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027}.
FT   DOMAIN          3..154
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          164..279
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   289 AA;  30043 MW;  54C1C1D1F116A155 CRC64;
     MTRVAFLGTG TMGAPMVRNL LGSGFEVHVW NRTTAKAASL REDGAVLAET PASAAEGADV
     LVTMLLDGDS TVRAAGEALN SLPPDAVWLQ MGTIGLSGMS EVVSACDGVS LVDAPVLGTR
     APAEQGTLTI LAAAVPEVRP RAEEVFDAVG QRTIWVSEDA TTAAGTKLKL AANNWVLELT
     NAVGESLALA QNLGLDPNLF LEAIRGTATD SPYAHLKGSA ILRDELAPSF TVSAAHKDAA
     LVAEAAGDSL RLDLARAAKE RFRRAEQAGY AEADMAAAYF ASFPERHDG
//
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