ID A0A099DA76_9ACTN Unreviewed; 252 AA.
AC A0A099DA76;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:KGI82979.1};
DE SubName: Full=TetR/AcrR family transcriptional regulator {ECO:0000313|EMBL:ASU80653.1};
GN ORFNames=CDG81_22975 {ECO:0000313|EMBL:ASU80653.1}, IL38_01845
GN {ECO:0000313|EMBL:KGI82979.1};
OS Actinopolyspora erythraea.
OC Bacteria; Actinomycetota; Actinomycetes; Actinopolysporales;
OC Actinopolysporaceae; Actinopolyspora.
OX NCBI_TaxID=414996 {ECO:0000313|EMBL:ASU80653.1, ECO:0000313|Proteomes:UP000215043};
RN [1] {ECO:0000313|EMBL:KGI82979.1, ECO:0000313|Proteomes:UP000029737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM90600 {ECO:0000313|EMBL:KGI82979.1,
RC ECO:0000313|Proteomes:UP000029737};
RX PubMed=25250723;
RA Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT "Identification and Characterization of a New Erythromycin Biosynthetic
RT Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-
RT Producing Halophilic Actinomycete Isolated from Salt Field.";
RL PLoS ONE 9:E108129-E108129(2014).
RN [2] {ECO:0000313|EMBL:ASU80653.1, ECO:0000313|Proteomes:UP000215043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU80653.1,
RC ECO:0000313|Proteomes:UP000215043};
RA Yin M., Tang S.;
RT "The complete genome sequence of moderately halophilic actinomycete
RT Actinopolyspora erythraea YIM 90600, the producer of novel erythromycin,
RT novel actinopolysporins A-C and tubercidin.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP022752; ASU80653.1; -; Genomic_DNA.
DR EMBL; JPMV01000007; KGI82979.1; -; Genomic_DNA.
DR RefSeq; WP_043569660.1; NZ_KN214174.1.
DR AlphaFoldDB; A0A099DA76; -.
DR KEGG; aey:CDG81_22975; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_9_0_11; -.
DR OrthoDB; 3210322at2; -.
DR Proteomes; UP000029737; Unassembled WGS sequence.
DR Proteomes; UP000215043; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR025996; MT1864/Rv1816-like_C.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF243; TETR-FAMILY TRANSCRIPTIONAL REGULATOR-RELATED; 1.
DR Pfam; PF13305; TetR_C_33; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00335}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 12..72
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 35..54
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT REGION 115..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 28098 MW; DAB6413BFBE1B1AA CRC64;
MNEVTRREQL RAATELDIRR HARELLIREG QEAVTLRAIA RELGITAPAL YRYYDSREDL
LARLAEDICG DLSAELNETM RDVEDEHLSK VFAVCRGFRR WALAHPREFA LVFATPANPG
GGRPGAEERD SPHAPAESTT RGDELGSVFL GVVGPLMAEG VTSSPPPSVP EELREGLADS
QRDLATAFNT HGIEIPPEAV SAEAVYMLLR WWARLYGQVA LEVFEKFPFD VSHADRLFES
MLEELGRESG LR
//
