GenomeNet

Database: UniProt
Entry: A0A099DAL7_9ACTN
LinkDB: A0A099DAL7_9ACTN
Original site: A0A099DAL7_9ACTN 
ID   A0A099DAL7_9ACTN        Unreviewed;       307 AA.
AC   A0A099DAL7;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   10-APR-2019, entry version 26.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=CDG81_00690 {ECO:0000313|EMBL:ASU77086.1}, IL38_00995
GN   {ECO:0000313|EMBL:KGI83228.1};
OS   Actinopolyspora erythraea.
OC   Bacteria; Actinobacteria; Actinopolysporales; Actinopolysporaceae;
OC   Actinopolyspora.
OX   NCBI_TaxID=414996 {ECO:0000313|EMBL:KGI83228.1, ECO:0000313|Proteomes:UP000029737};
RN   [1] {ECO:0000313|EMBL:KGI83228.1, ECO:0000313|Proteomes:UP000029737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM90600 {ECO:0000313|EMBL:KGI83228.1,
RC   ECO:0000313|Proteomes:UP000029737};
RX   PubMed=25250723;
RA   Chen D., Feng J., Huang L., Zhang Q., Wu J., Zhu X., Duan Y., Xu Z.;
RT   "Identification and Characterization of a New Erythromycin
RT   Biosynthetic Gene Cluster in Actinopolyspora erythraea YIM90600, a
RT   Novel Erythronolide-Producing Halophilic Actinomycete Isolated from
RT   Salt Field.";
RL   PLoS ONE 9:E108129-E108129(2014).
RN   [2] {ECO:0000313|EMBL:ASU77086.1, ECO:0000313|Proteomes:UP000215043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIM 90600 {ECO:0000313|EMBL:ASU77086.1,
RC   ECO:0000313|Proteomes:UP000215043};
RA   Yin M., Tang S.;
RT   "The complete genome sequence of moderately halophilic actinomycete
RT   Actinopolyspora erythraea YIM 90600, the producer of novel
RT   erythromycin, novel actinopolysporins A-C and tubercidin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP022752; ASU77086.1; -; Genomic_DNA.
DR   EMBL; JPMV01000001; KGI83228.1; -; Genomic_DNA.
DR   RefSeq; WP_043569471.1; NZ_KN214174.1.
DR   STRING; 414996.IL38_00995; -.
DR   EnsemblBacteria; KGI83228; KGI83228; IL38_00995.
DR   KEGG; aey:CDG81_00690; -.
DR   KO; K04518; -.
DR   OrthoDB; 1280729at2; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000029737; Unassembled WGS sequence.
DR   Proteomes; UP000215043; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029737,
KW   ECO:0000313|Proteomes:UP000215043};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029737}.
FT   DOMAIN        3    182       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      196    274       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        175    175       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   307 AA;  32788 MW;  9325B55AF47C9290 CRC64;
     MPRIAYLGPQ GTFTEQATRA LTADFAAELI AHDTVHSALD AVRLGDVEAA GVPMENSVEG
     AVAATLDGLV GGDPLVAVAE LVLPIRFDVL LRPEVDPLRA TSVASHPHAL AQVRGWLSER
     LPRAQDVPTA STATAAAEVE SGTADAAVVA PVATHYHPEL TRLASEVADV DDAVTRFLLV
     RRPGRLPEPT GADRTSIAVV AHDEVGALGE VLSELSLRGI NLSRIESRPT KDRLGAYRFF
     LDFDGHVADT RIGDALTGLH RRCFEVRFLG SFPKADSKPV NVRAADSEQA FRRSMGWLDE
     VRAGRTA
//
DBGET integrated database retrieval system