ID A0A099F3C0_9RHOB Unreviewed; 801 AA.
AC A0A099F3C0;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=IC63_11820 {ECO:0000313|EMBL:KGJ04677.1};
OS Paracoccus sphaerophysae.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=690417 {ECO:0000313|EMBL:KGJ04677.1, ECO:0000313|Proteomes:UP000029917};
RN [1] {ECO:0000313|EMBL:KGJ04677.1, ECO:0000313|Proteomes:UP000029917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAMBI 3106 {ECO:0000313|EMBL:KGJ04677.1,
RC ECO:0000313|Proteomes:UP000029917};
RA McGinnis J.M., Wolfgang W.J.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KGJ04677.1, ECO:0000313|Proteomes:UP000029917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAMBI 3106 {ECO:0000313|EMBL:KGJ04677.1,
RC ECO:0000313|Proteomes:UP000029917};
RA Mingle L.A., Cole J.A., Lapierre P., Musser K.A.;
RT "Paracoccus sanguinis sp. nov., isolated from clinical specimens of New
RT York State patients.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGJ04677.1}.
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DR EMBL; JRKS01000040; KGJ04677.1; -; Genomic_DNA.
DR RefSeq; WP_036720479.1; NZ_JRKS01000040.1.
DR AlphaFoldDB; A0A099F3C0; -.
DR STRING; 690417.IC63_11820; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000029917; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000029917}.
FT DOMAIN 32..317
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 318..593
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 53..60
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 801 AA; 88146 MW; 6DEF8D7C584F4D84 CRC64;
MSQFDDADAF EAAARPSLSQ RAMAGRAAPY LDGLNPAQRQ AVETLDGPVL LLAGAGTGKT
RALTTRIAHL LTQGRATPGR ILAVTFTNKA AREMKSRVAH LLGETVEGMP WLGTFHSVSV
KILRRHAELV GGDGLHLKPS FTILDTDDQI RLLKQLIAAE NIDEKRWPAR MLAGLIDDWK
NRALTPSRVP SGESSAFDGK GVALYSQYQR RLLELNATDF GDLLLHCVTI FQAHPDVLGQ
WQDRFSYILV DEYQDTNVAQ YLWLRLLAAR HRNICCVGDD DQSIYGWRGA EVGNILRFET
DFPGAQVIRL EQNYRSTPHI LAAASGLIAA NKGRLGKTLW TEAEGGEKLR LIGHWDSEAE
ARWIGEEIEA FHGGHRHSVG RRSLNDIAIL VRAAHQMRAF EDRFMTIGLP YRVIGGPRFY
ERLEIRDAMA YFRLAVSPTD DLAFERIANT PKRGLGEKGL QTIQRVARAS GLSLLEGAVA
ATASGELTGK AANQMREFGA AMGRWHADAI DSTVNHVELA ERILDESGYT AMWQNDKAPD
APGRLENLKE LVKALEEFEN LQGFLEHVAL VMDASEGEQA EEVSIMTLHA AKGLEYPIVF
LPGWEDGLFP SQRSMDESGL KGLEEERRLA YVGITRAEEL ATITFAGNRR MYGQWQSSLP
SRFIDELPED HVEVLTPPGL YGGGYGAAMA FAGANGGSEM HQRASNADVY NSPGWKRMQE
RAAARAAPVH RTPIVIDADP GARFAVGERV FHQKFGSGTV MGIAEDTLTV QFPAGFKTIK
AAYVQPASDA ARDITPDDVP F
//
