ID A0A099I889_CLOIN Unreviewed; 130 AA.
AC A0A099I889;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=HIT domain-containing protein {ECO:0000313|EMBL:MZH58936.1};
DE SubName: Full=HIT family hydrolase {ECO:0000313|EMBL:KGJ53427.1};
DE SubName: Full=HIT family protein {ECO:0000313|EMBL:ASU18104.1};
GN ORFNames=ADH65_06005 {ECO:0000313|EMBL:ASU18104.1}, CIAN88_08350
GN {ECO:0000313|EMBL:KGJ53427.1}, GT649_02735
GN {ECO:0000313|EMBL:MZH58936.1}, I5Q87_01405
GN {ECO:0000313|EMBL:QQR26651.1};
OS Clostridium innocuum.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Coprobacillaceae; Thomasclavelia.
OX NCBI_TaxID=1522 {ECO:0000313|EMBL:KGJ53427.1, ECO:0000313|Proteomes:UP000030008};
RN [1] {ECO:0000313|EMBL:KGJ53427.1, ECO:0000313|Proteomes:UP000030008}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AN88 {ECO:0000313|EMBL:KGJ53427.1,
RC ECO:0000313|Proteomes:UP000030008};
RA Feng Y., Chiu C.-H.;
RT "Clostridium innocuum, an unnegligible vancomycin-resistant pathogen
RT causing extra-intestinal infections.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ASU18104.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I46 {ECO:0000313|EMBL:ASU18104.1};
RX PubMed=29051233;
RA Garzetti D., Brugiroux S., Bunk B., Pukall R., McCoy K.D., Macpherson A.J.,
RA Stecher B.;
RT "High-Quality Whole-Genome Sequences of the Oligo-Mouse-Microbiota
RT Bacterial Community.";
RL Genome Announc. 5:e00758-17(2017).
RN [3] {ECO:0000313|Proteomes:UP000214713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=I46 {ECO:0000313|Proteomes:UP000214713};
RA Garzetti D.;
RT "High-quality whole genome sequences of the Oligo-Mouse-Microbiota.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:MZH58936.1, ECO:0000313|Proteomes:UP000478871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A13 {ECO:0000313|EMBL:MZH58936.1,
RC ECO:0000313|Proteomes:UP000478871};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
RN [5] {ECO:0000313|EMBL:QQR26651.1, ECO:0000313|Proteomes:UP000595712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=I46 {ECO:0000313|EMBL:QQR26651.1,
RC ECO:0000313|Proteomes:UP000595712};
RA Marbouty M., Lamy-Besnier Q., Debarbieux L., Koszul R.;
RT "Closed and high quality bacterial genomes of the OMM12 community.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP022722; ASU18104.1; -; Genomic_DNA.
DR EMBL; JQIF01000039; KGJ53427.1; -; Genomic_DNA.
DR EMBL; WWTM01000004; MZH58936.1; -; Genomic_DNA.
DR EMBL; CP065320; QQR26651.1; -; Genomic_DNA.
DR RefSeq; WP_002608825.1; NZ_WWTY01000004.1.
DR GeneID; 61925720; -.
DR Proteomes; UP000030008; Unassembled WGS sequence.
DR Proteomes; UP000214713; Chromosome.
DR Proteomes; UP000478871; Unassembled WGS sequence.
DR Proteomes; UP000595712; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd01277; HINT_subgroup; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039384; HINT.
DR InterPro; IPR019808; Histidine_triad_CS.
DR InterPro; IPR001310; Histidine_triad_HIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR46648:SF1; ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1; 1.
DR PANTHER; PTHR46648; HIT FAMILY PROTEIN 1; 1.
DR Pfam; PF01230; HIT; 1.
DR PRINTS; PR00332; HISTRIAD.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS00892; HIT_1; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KGJ53427.1}.
FT DOMAIN 3..111
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 95..99
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 97
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ SEQUENCE 130 AA; 14730 MW; C0DD8D0A04943588 CRC64;
MCIFCSIVKG EIPATRIYED DTVLAILDIS QVTKGHTLVI PKQHTENFMS CEPELMKHVM
EVAQMLAKRI MERTHAEGMN VLSNIHEVAG QSVMHFHVHL IPRYSEQDAC VIRFDKSDPQ
DLDAIGTLLK
//
