ID A0A099IA39_CLOIN Unreviewed; 442 AA.
AC A0A099IA39;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN ECO:0000313|EMBL:ASU17906.1};
GN ORFNames=ADH65_04975 {ECO:0000313|EMBL:ASU17906.1}, CIAN88_07290
GN {ECO:0000313|EMBL:KGJ53773.1}, I5Q87_00380
GN {ECO:0000313|EMBL:QQR26455.1};
OS Clostridium innocuum.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Coprobacillaceae; Thomasclavelia.
OX NCBI_TaxID=1522 {ECO:0000313|EMBL:KGJ53773.1, ECO:0000313|Proteomes:UP000030008};
RN [1] {ECO:0000313|EMBL:KGJ53773.1, ECO:0000313|Proteomes:UP000030008}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AN88 {ECO:0000313|EMBL:KGJ53773.1,
RC ECO:0000313|Proteomes:UP000030008};
RA Feng Y., Chiu C.-H.;
RT "Clostridium innocuum, an unnegligible vancomycin-resistant pathogen
RT causing extra-intestinal infections.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ASU17906.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I46 {ECO:0000313|EMBL:ASU17906.1};
RX PubMed=29051233;
RA Garzetti D., Brugiroux S., Bunk B., Pukall R., McCoy K.D., Macpherson A.J.,
RA Stecher B.;
RT "High-Quality Whole-Genome Sequences of the Oligo-Mouse-Microbiota
RT Bacterial Community.";
RL Genome Announc. 5:e00758-17(2017).
RN [3] {ECO:0000313|Proteomes:UP000214713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=I46 {ECO:0000313|Proteomes:UP000214713};
RA Garzetti D.;
RT "High-quality whole genome sequences of the Oligo-Mouse-Microbiota.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:QQR26455.1, ECO:0000313|Proteomes:UP000595712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=I46 {ECO:0000313|EMBL:QQR26455.1,
RC ECO:0000313|Proteomes:UP000595712};
RA Marbouty M., Lamy-Besnier Q., Debarbieux L., Koszul R.;
RT "Closed and high quality bacterial genomes of the OMM12 community.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
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DR EMBL; CP022722; ASU17906.1; -; Genomic_DNA.
DR EMBL; JQIF01000033; KGJ53773.1; -; Genomic_DNA.
DR EMBL; CP065320; QQR26455.1; -; Genomic_DNA.
DR RefSeq; WP_009269138.1; NZ_VUMA01000002.1.
DR Proteomes; UP000030008; Unassembled WGS sequence.
DR Proteomes; UP000214713; Chromosome.
DR Proteomes; UP000595712; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR NCBIfam; TIGR00237; xseA; 1.
DR PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_00378};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378}.
FT DOMAIN 6..100
FT /note="OB-fold nucleic acid binding"
FT /evidence="ECO:0000259|Pfam:PF13742"
FT DOMAIN 124..432
FT /note="Exonuclease VII large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02601"
SQ SEQUENCE 442 AA; 49687 MW; 90DAC65F7D235E57 CRC64;
MSQNVYSVSA LVHYIKQTLD NDIRIQSILI KGEISNFTNH RSGHWYFTLK DARSKISCVM
FSSHARRCNI LLKEGMKVIV TASVSMYEAG GSVQLYVTAV RSDGLGDLFL QLEEVKKKLA
AQGLFDPQKK KPLPQYPMRI GVITAKTGAA VQDILTTISR RWPLAEVVVY PSLVQGIQAS
GAIVENLRKA DQGGHDVILL ARGGGPIEDL WCFNEEAVAR AVFAMHTVIV TGVGHETDTT
LVDYVSDARA PTPTAAAELI TPDLEEVRMN VSLMRRRLVK DMETRLHMAK QALEPIRSHR
YMRDPLSYIR EEEMKLAMHV QQLSIVEATV AAMAMQLKQN SHKLAIHSER LFQKNTRSIA
ESRLRLTQAL HNYDTLRKRQ IGNISALLDA YSPLKSLSRG YAIAYHGDEV ISSVDAVEQN
DRLRLRMQDG YLYTNIEKKE KL
//
