ID A0A099NY59_PICKU Unreviewed; 1243 AA.
AC A0A099NY59;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Rab-GAP TBC domain-containing protein {ECO:0000259|PROSITE:PS50086};
GN ORFNames=JL09_g3297 {ECO:0000313|EMBL:KGK37555.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK37555.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK37555.1}.
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DR EMBL; JQFK01000034; KGK37555.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099NY59; -.
DR VEuPathDB; FungiDB:C5L36_0C01440; -.
DR eggNOG; KOG2058; Eukaryota.
DR eggNOG; KOG2189; Eukaryota.
DR HOGENOM; CLU_005230_0_1_1; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR PANTHER; PTHR11629:SF59; V-TYPE PROTON ATPASE SUBUNIT A, GOLGI ISOFORM; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 447..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1158..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 958..1166
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 892..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 101..128
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 900..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1243 AA; 141841 MW; 2C368BE8631798F4 CRC64;
MSLVQFYIPS EVARECVAVL GDMGNVQFRD MNQNVSSFQR AFVKEIRSYD QVERQLKYLT
GLIQKQEIKI RVNDHDELIM PPSTDYRQFY DSPSHLSASA LEELLHEIAS VESKVRELSF
QKDEMSQRKA DLTQHRLVLQ NTRQFFESRL SLDLDDSDSL FNQVRLSTES SDSFIISDDE
GDGVLLESGL GNTNHGGNSI STGRNELNVF GSTMNFISGI IDTEKFLILE KICWRTLRGN
VYTNHVPLPE PIIDIKTGEP SFKSVFLIFT HGESLISRCK RIVESLDGKL YNVDSDYEVY
KQELRTVNNK IKDINEVLLY TNERLLIELK QVALDIEKWK IIIKREVSIY EVLNLFNYDS
TRRCVIGEGW IPNDDLTYIN MALRDVTNKF DAGLSTIVNL MITNKTPPTY HKTNKFTGAF
QSIIDAYGIA TYQEVNPGLA TIVTFPFMFA IMFGDLGHGL ILFIAALTLV LCENRISKIK
NRDEIFDMAY TGRYILLLMG VFSMYTGIIY NDLFSKSMSL FKSGWKWPNG FKEGTSIVGT
QRGVYPLGLD PAWHGTENNL LFTNSYKMKL SILMGFIHMS YSFYFALVNY RFFNSRVDII
GNFIPGLLFM QSIFGYLTIT IVYKWCVDWI AIGKPAPSLL NMLINMFLSP GTIEDKLYPG
QGPLQVFLVL IALVCVPWLL LYKPLTLKKM NSNKIQLGYA DVNGPDNTNS RISVESVPYT
EEAEDLFDRG SNTIQERLSI DADVGLLEDE NGEEEEPFSF GDAMVHQVIH TIEFCLNCVS
HTASYLRLWA LSLAHNQLSA VLWEMTIQNS FKPYSETGWV GSIIVFFLFG MWFVLTVCIL
VVMEGTSAML HSLRLHWVEA MSKFFEGEGY AYQPFSFYRI ILDMQAAEME EERKLNRKSS
STESSGSIRN KPSKPSISDS KQRGRKKDAL EKFIESPQQL LKSSLSQLRH TILVEGLPVE
CPYRSYIWSI LLSGAPIESE WYSGIVSRGK VNSSNVVDTK FVHFGDKIEN DVFRTFQNNK
KFWSKIEEGE LIRILNVFAW CVIEDEQVDF KVGSKISISP YVQGMNVLVA PLAYVCRSEP
QAFALLYRLL MVEMPRYITP TLAGVMDGVR LVDLVLKTVD RRLYEYLDQS MANAKIYALP
SVLTLCACTP PLEEVLKLWD FLFSFGIHMN VVLIVAQLLL IRGELMNTKN PMVLLRNFPQ
LESSKIIKLS LSIARNIPDS LYDLIVRHTF DESVTLEIDD YKI
//
