ID A0A099P0H3_PICKU Unreviewed; 653 AA.
AC A0A099P0H3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN ORFNames=CAS74_002253 {ECO:0000313|EMBL:OUT22514.1}, JL09_g2482
GN {ECO:0000313|EMBL:KGK38370.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK38370.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
RN [2] {ECO:0000313|EMBL:KGK38370.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|EMBL:KGK38370.1};
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for Succinic Acid Production.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OUT22514.1, ECO:0000313|Proteomes:UP000195871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ckrusei653 {ECO:0000313|EMBL:OUT22514.1,
RC ECO:0000313|Proteomes:UP000195871};
RA Cuomo C., Forche A., Young S., Abouelleil A., Cao P., Chapman S.,
RA Cusick C., Shea T., Nusbaum C., Birren B.;
RT "The Genome Sequence of Candida krusei Ckrusei653.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK38370.1}.
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DR EMBL; JQFK01000020; KGK38370.1; -; Genomic_DNA.
DR EMBL; NHMM01000003; OUT22514.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099P0H3; -.
DR VEuPathDB; FungiDB:C5L36_0D02790; -.
DR eggNOG; KOG1325; Eukaryota.
DR HOGENOM; CLU_014602_0_0_1; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR Proteomes; UP000195871; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF33; LYSOPHOSPHOLIPASE 1-RELATED; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103}; Signal {ECO:0000256|RuleBase:RU362103}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT CHAIN 17..653
FT /note="Lysophospholipase"
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT /id="PRO_5005108349"
FT DOMAIN 43..599
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
SQ SEQUENCE 653 AA; 71622 MW; 8B8380CEE62349C7 CRC64;
MFPITTLFAL AATASAAIFN DTDITYAPYE GYCPSYNSSA IYNTTTHEGY IRSNYLISQD
EYSYISARKV KTTDKLISFL DNLEIPDYNG TSFANYFNDL NQTGINIGLS FSGGGFRALF
NGAGEIMALD SRTTGNSTLK GLLDASTYIS GISGGSIMVN TLVFNNWTSV EDIVYSNETS
IWNTTAPPVS TEISFWLNLI SQVEPKKEAG YEITLADLYG RILSKYMFEK DYDDYGINTL
YSDVPYIEAF QDFDMPFPII AASGNVNNNM SAYTPNLFEI TPYEFGSFSP LVGGFIPIDI
LGTQFDAGMP NSSYDCTYEF DNVGWLTAAS SNILVAFQES LVAALSGNST ASTIDVVGTN
VSVSYVEALV GLVNKNVNDT LFAVVDNPFF NSSLSSNDSD IPYGDLLKLI DGGYSEVIPL
DPVLVPSREV DVVFAFDNSG SDETDNYPDG DSLFATEERW AEAFPDDVFY ALPNSTEEFV
ELGLNKRPVF FGCNGSSLVT DQYNPNATVE FNVMKPLLVY IPNYNASANS NITGFQLTYE
ERNAIVENGF DIVQNDDDED FAQCVGCAII RRSEERAGIE ISPFCAKCFN RYCFESLSDE
QYDNSTISEV IPTSIYSSSA LPSKLSSLLT RSTNSVSFPT TFSKPTHTST TSV
//
