ID A0A099P2A3_PICKU Unreviewed; 1119 AA.
AC A0A099P2A3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=JL09_g1672 {ECO:0000313|EMBL:KGK39168.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK39168.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGK39168.1}.
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DR EMBL; JQFK01000011; KGK39168.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099P2A3; -.
DR VEuPathDB; FungiDB:C5L36_0A03060; -.
DR eggNOG; KOG0890; Eukaryota.
DR HOGENOM; CLU_000178_3_0_1; -.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF124; SERINE_THREONINE-PROTEIN KINASE MEC1; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 93..658
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 769..1076
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1087..1119
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 1119 AA; 129373 MW; 0828DDCFE76FBC2A CRC64;
MCPESNIAKK NIQQEFMSIL SNDLSLVQNQ VIREGLKKYF VTIIEIFQFL KAWSSKVKDE
EDASKASNKN NSKIKRTGVQ RIGKFLKYFP HDIMAKRCAD CDIYEGSILF LENGYKDGII
PKDVFFSTLK DMYVKLEDYD QLHGALKLFS TNSLSDKLLQ FKFNEDIQIS NESLRAIAQY
NFDDDPNQKG TTQNASVTEL FEVLNKNCEY EQLLLNLKNY EAKLDDGPNQ YLINTDWILH
GIQASIYTGD MDNLERWSYS SQNSNAIAIS GSDMSILYEI AQGLIALHKQ AIPSCCRHIE
NAIEYIGLAI SNSQNFIQKK ISDYMILLHS LYDFQILAKM NSRDDKVIQI LKNRLDFSKQ
DYKSVWKIHS LKSSIYKLHP GKDFQTLYKD SLVEGCRILR ENGKLPQATR LITKALVLNE
NDDNVEMTQA STMLMNVEFS KLFWAQNDYE TALKTLKLVV DNLHTKNPYY LDFSLTYLNW
MDVSAEGSSD EIKERYNALI RERVYDNSGD VNYQYAVYLN KLLEAQILEE SDGSLDYAVI
KQYLLAVSAS KKYVHEILPK AVTLWLDYYH KYIDIEPTCN ITKKLSDSRH NSYQLINKTV
EKSVSNLGKK WYIVLSQIIS RITHDDKNIT ELISKVIVEL TVKYPWLILY SVFSQARSVD
EKRKAIGTMI LTKLQDSRNH TDSKTLQLPK LIASGLILLE SIMSVCNTTN KFKHPKSGTL
YKDLYKDLGF DYPRDSECLA LALPIKENVD LLYNLKNDVD KHVIFYSKFH EKVKILFSLQ
QPKRVRVTGT NGETYFLLFK PRDDLRKDNK VMEFSTVMND LLSKNYETQT RNMQIKSFAA
TPLNETTGII EWVQNVVTLR HIIDGQFKRQ NIIINMRNMK NEFGDAKPSE KRAIFESYLD
KFPPILGKWM IENFPNIYKW YRARETYTRS LAVMSIVGYL IGVGDRHLDN IMINRKTGII
MHIDFDCMFE KGKKLSVPEI VPFRLTPHLI EAMGVLGYEG AFRKSCELTM SIIRENENIL
MNFLESFIHD PLMDWRSGSS DGRASDDKAL TRIKKQQEKV YKILRRKIKG ILSKEDDNTG
YRDSGGLSVS VSLQVDLLIQ TAVSHENLSK MFFGWMPYL
//
