ID A0A099P306_PICKU Unreviewed; 856 AA.
AC A0A099P306;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 13-SEP-2023, entry version 39.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
GN ORFNames=BOH78_0567 {ECO:0000313|EMBL:ONH77103.1}, C5L36_0B10680
GN {ECO:0000313|EMBL:AWU75832.1}, JL09_g1500
GN {ECO:0000313|EMBL:KGK39315.1};
OS Pichia kudriavzevii (Yeast) (Issatchenkia orientalis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Pichia.
OX NCBI_TaxID=4909 {ECO:0000313|EMBL:KGK39315.1, ECO:0000313|Proteomes:UP000029867};
RN [1] {ECO:0000313|Proteomes:UP000029867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|Proteomes:UP000029867};
RX PubMed=25159171; DOI=10.1186/s12934-014-0121-4;
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for succinic acid production.";
RL Microb. Cell Fact. 13:121-121(2014).
RN [2] {ECO:0000313|EMBL:KGK39315.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SD108 {ECO:0000313|EMBL:KGK39315.1};
RA Xiao H., Shao Z., Jiang Y., Dole S., Zhao H.;
RT "Exploiting Issatchenkia orientalis SD108 for Succinic Acid Production.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000189274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129 {ECO:0000313|Proteomes:UP000189274};
RX PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT Zimbabwe.";
RL Genome Announc. 5:E00064-E00064(2017).
RN [4] {ECO:0000313|EMBL:ONH77103.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129 {ECO:0000313|EMBL:ONH77103.1};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AWU75832.1, ECO:0000313|Proteomes:UP000249293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS573 {ECO:0000313|EMBL:AWU75832.1,
RC ECO:0000313|Proteomes:UP000249293};
RA Douglass A.P., Offei B., Braun-Galleani S., Coughlan A.Y., Martos A.,
RA Ortiz-Merino R.A., Byrne K.P., Wolfe K.H.;
RT "Population genomics shows no distinction between pathogenic Candida krusei
RT and environmental Pichia kudriavzevii: One species, four names.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
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DR EMBL; CP028774; AWU75832.1; -; Genomic_DNA.
DR EMBL; JQFK01000010; KGK39315.1; -; Genomic_DNA.
DR EMBL; MQVM01000002; ONH77103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099P306; -.
DR STRING; 4909.A0A099P306; -.
DR VEuPathDB; FungiDB:C5L36_0B10680; -.
DR eggNOG; KOG1096; Eukaryota.
DR HOGENOM; CLU_003782_2_2_1; -.
DR OrthoDB; 20951at2759; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000029867; Unassembled WGS sequence.
DR Proteomes; UP000189274; Unassembled WGS sequence.
DR Proteomes; UP000249293; Chromosome 2.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF0; AMP DEAMINASE; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000249293}.
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 99734 MW; 81EB4B6547149899 CRC64;
MSEPKENFSN VDQCNRGMQF LSLSGEGSSH PTSSTHPHEE AIEDYDDNEI YDKLTDLNRK
SKKDGFFDYS MIHEDEEDAA DEKSINPHFS YSEEQMLKDT DAKIRAFSNL ASSPRNSRSS
SASSSVHPAR RPSMADFVVP PIPTVFNATT PKISRSNSRF SYNPTTHEMS PNISNAAPPG
ATTPVYQRDP FVAQKHQQII NDIAKDHKFK LGDFFNNDHN STSDIPSLEL MELYKQIKWC
VETRKKYIDV SLQIPDENPK NKEGWKIYPN PPPPFWKAQN RRALDSSTGS YHMDEGTRNV
DSRDFDFDKC EIPGPDEAVD FMVDDEDTYQ IVDRKTGEKL VNVPTIKDYY MDLEKITNIA
SDGPMKSFAF KRLQYLEARW NLYYLLNEHE ETAESKKNPH RDFYNVRKVD VHVHHSACMN
QKHLLRFIKH KIRHYPNEKV IKRDGQVLTL QQVFDSLNLT AYDLSIDTLD MHAHRDTFHR
FDKFNLKYNP MGESRLREIF LKTDNFLQGR YLAEITKEVF DDLESSKYQM AEYRISIYGR
SIDEWDKLAS WVIDNKLFSH NVRWLVQVPR LYNIYKKGGQ VQSFREIVDN IFKPLFEVTR
NPQSHPKLHV FLQRVIGFDS VDDESKIDRR FHKKFPFPSI WNSEYNPPYS YYLYYLYSNI
TSLNQWRKRR GFNTFSLRPH SGEAGDPEHL ISAFLTSESI NHGILLRKVP FVQYLYYLCQ
IGIAMSPLSN NALFLTYDKN PFPTYFKRGL NIALSTDDPL QFSYTREPLI EEYSVAAQIW
KLSNVDMSEL AKNSVLMSGF EYELKKHWVG HNFYLGGVEG NDVAKTNVPD LRVSYRTTTL
ETEFALIEYY TSIDGI
//
