ID   A0A099TWF2_9HELI        Unreviewed;       597 AA.
AC   A0A099TWF2;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=4-hydroxyacetophenone monooxygenase {ECO:0000313|EMBL:STQ85955.1};
DE            EC=1.14.13.84 {ECO:0000313|EMBL:STQ85955.1};
DE   SubName: Full=NAD(P)/FAD-dependent oxidoreductase {ECO:0000313|EMBL:TLE01092.1};
GN   Name=hapE {ECO:0000313|EMBL:STQ85955.1};
GN   ORFNames=LS73_002105 {ECO:0000313|EMBL:TLE01092.1}, NCTC12714_00745
GN   {ECO:0000313|EMBL:STQ85955.1};
OS   Helicobacter muridarum.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=216 {ECO:0000313|EMBL:STQ85955.1, ECO:0000313|Proteomes:UP000255139};
RN   [1] {ECO:0000313|EMBL:TLE01092.1, ECO:0000313|Proteomes:UP000029922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ST1 {ECO:0000313|EMBL:TLE01092.1,
RC   ECO:0000313|Proteomes:UP000029922};
RX   PubMed=25428971;
RA   Sheh A., Shen Z., Fox J.G.;
RT   "Draft genome sequences of eight enterohepatic helicobacter species
RT   isolated from both laboratory and wild rodents.";
RL   Genome Announc. 2:e01218-e01214(2014).
RN   [2] {ECO:0000313|EMBL:STQ85955.1, ECO:0000313|Proteomes:UP000255139}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC12714 {ECO:0000313|EMBL:STQ85955.1,
RC   ECO:0000313|Proteomes:UP000255139};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UGJE01000002; STQ85955.1; -; Genomic_DNA.
DR   EMBL; JRPD02000003; TLE01092.1; -; Genomic_DNA.
DR   RefSeq; WP_034558416.1; NZ_UGJE01000002.1.
DR   AlphaFoldDB; A0A099TWF2; -.
DR   STRING; 216.LS73_06555; -.
DR   OrthoDB; 9790219at2; -.
DR   Proteomes; UP000029922; Unassembled WGS sequence.
DR   Proteomes; UP000255139; Unassembled WGS sequence.
DR   GO; GO:0033767; F:4-hydroxyacetophenone monooxygenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR43539:SF78; FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR43539; FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220); 1.
DR   Pfam; PF13738; Pyr_redox_3; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE   4: Predicted;
KW   Monooxygenase {ECO:0000313|EMBL:STQ85955.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:STQ85955.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000255139}.
SQ   SEQUENCE   597 AA;  68234 MW;  A0B47AAA8A7F61BB CRC64;
     MKKNYINTLQ SWLNNFEQAL STSHTLTDVL DLFQDSCYWR DLISLTWNII TLEGKPSIKQ
     MLQSQLTSSK PTNFKVEGDI NSYDDIIEGF FTFETKVFRG KGYIRLKNGL CWTLLTVANE
     LKGFEEKKNK NRIKGAEHGI NKNRLTWLEK KQKEETELGY SKQPYVLIIG GGQGGIALGA
     RLKRLEVPTL IVDAHPKPGD QWRNRYKSLC LHDPIWYDHL PYLPFPDDWP VFSPKDKIAD
     WLECYVKIME LNYWSSTKCV KASYDDTNKE WIATVEKEGK EIILRPKHVV FALGMSGVPN
     IPKPKGYDIF KGEQQHSSEH KSSDLYKGKK VVVLGSNNSA HDICAALWEN DADVTMIQRS
     STHIVRSDSL MELALKGLYS EEALENGITT DKADLLFASV PFRIMADFHK PVYDEIKKRD
     KDLYDRLEKR GFLLDFGDDG SGLFMKYLRR GSGYYIDVGA SELVANGDIK LENGNIKELK
     ENSVVLTNGK ELEADLVIYA TGFSSMNFWV AKIVSQEVAD KVGKVWGLGS NTKKDPGPWE
     GELRNMWKPT QQENLWFHGG NLHQSRHYSL YLSLQLKARY EGLETPVYGL AKVHHLY
//