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Database: UniProt
Entry: A0A099VBE0_9HELI
LinkDB: A0A099VBE0_9HELI
Original site: A0A099VBE0_9HELI 
ID   A0A099VBE0_9HELI        Unreviewed;       438 AA.
AC   A0A099VBE0;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=LS81_10520 {ECO:0000313|EMBL:KGL30122.1};
OS   Helicobacter trogontum.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=50960 {ECO:0000313|EMBL:KGL30122.1, ECO:0000313|Proteomes:UP000029878};
RN   [1] {ECO:0000313|EMBL:KGL30122.1, ECO:0000313|Proteomes:UP000029878}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700114 {ECO:0000313|EMBL:KGL30122.1,
RC   ECO:0000313|Proteomes:UP000029878};
RA   Sheh A., Shen Z., Fox J.G.;
RT   "Genome sequencing of Helicobacter and Campylobacter species isolated
RT   from rodents.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGL30122.1}.
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DR   EMBL; JRPL01000004; KGL30122.1; -; Genomic_DNA.
DR   EnsemblBacteria; KGL30122; KGL30122; LS81_10520.
DR   Proteomes; UP000029878; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029878};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      132    264       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      342    412       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     140    147       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   438 AA;  50897 MW;  EB534D44A3B2EA33 CRC64;
     MNALLEQLQY EIPQKEYQQY ISQISFDSIN STPNHLIFTT PNIFIANWAK NKYTDLILKI
     LKVKAEEKIK IDFIANNKQN KINTENNKSK KYIISNNQTF RNEYASFKNF IVGECNRFAF
     ETAKEISKNQ AKWNPLLIYG NTGLGKTHLL NAICNAVYER LPNANIIYIT AENMFNEYRL
     RVQNNTMQHF RERFRTCDYL LIDDVQFLSN TEKFQEEFFN TFNIIVQNGG QIVMTSDKAP
     KFIDKLEKRL KSRFAGGMMT KIESPELEMK INIIKQKCAL NNITLDQTII NFIATQLHDN
     IREIEGTIID IYGNMSIMNI PITLDIVQNI LKDREIEAKT TNFDDVVNLI AKEYNIKPSE
     IKNKTRGKKI IAKARKIVTY IAREAINTTF PYIATELNLK DHSAVSKQIK SIKQEMEKDN
     ALKIEVQNLL SKLKQNVQ
//
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