ID A0A099VYT5_9LIST Unreviewed; 294 AA.
AC A0A099VYT5;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Ribosomal RNA small subunit methyltransferase A {ECO:0000256|HAMAP-Rule:MF_00607};
DE EC=2.1.1.182 {ECO:0000256|HAMAP-Rule:MF_00607};
DE AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase {ECO:0000256|HAMAP-Rule:MF_00607};
DE AltName: Full=16S rRNA dimethyladenosine transferase {ECO:0000256|HAMAP-Rule:MF_00607};
DE AltName: Full=16S rRNA dimethylase {ECO:0000256|HAMAP-Rule:MF_00607};
DE AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase {ECO:0000256|HAMAP-Rule:MF_00607};
GN Name=rsmA {ECO:0000256|HAMAP-Rule:MF_00607,
GN ECO:0000313|EMBL:MBC1247164.1};
GN Synonyms=ksgA {ECO:0000256|HAMAP-Rule:MF_00607};
GN ORFNames=EP57_16360 {ECO:0000313|EMBL:KGL37601.1}, HB759_15265
GN {ECO:0000313|EMBL:MBC1333304.1}, HB809_15100
GN {ECO:0000313|EMBL:MBC1309031.1}, HB810_11140
GN {ECO:0000313|EMBL:MBC1247164.1}, HB811_12630
GN {ECO:0000313|EMBL:MBC1317620.1}, HB836_12355
GN {ECO:0000313|EMBL:MBC1402375.1}, HB900_14680
GN {ECO:0000313|EMBL:MBC1575714.1}, HB902_07850
GN {ECO:0000313|EMBL:MBC1561985.1}, HB904_07080
GN {ECO:0000313|EMBL:MBC1615943.1}, HB907_09995
GN {ECO:0000313|EMBL:MBC1565740.1}, HCA52_06370
GN {ECO:0000313|EMBL:MBC1793036.1}, HCA67_13605
GN {ECO:0000313|EMBL:MBC2068806.1}, HCA73_07235
GN {ECO:0000313|EMBL:MBC1912436.1}, HCA78_04020
GN {ECO:0000313|EMBL:MBC2002925.1}, HCB06_02845
GN {ECO:0000313|EMBL:MBC2115548.1}, HCB25_12295
GN {ECO:0000313|EMBL:MBC2244852.1}, HCB26_06895
GN {ECO:0000313|EMBL:MBC2166293.1}, HCB69_10695
GN {ECO:0000313|EMBL:MBC2284847.1}, HCC36_13205
GN {ECO:0000313|EMBL:MBC2294194.1}, HCJ32_09870
GN {ECO:0000313|EMBL:MBC1945271.1}, HCJ43_13080
GN {ECO:0000313|EMBL:MBC1976209.1};
OS Listeria booriae.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1552123 {ECO:0000313|EMBL:KGL37601.1, ECO:0000313|Proteomes:UP000029844};
RN [1] {ECO:0000313|EMBL:KGL37601.1, ECO:0000313|Proteomes:UP000029844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL A5-0281 {ECO:0000313|EMBL:KGL37601.1,
RC ECO:0000313|Proteomes:UP000029844};
RA den Bakker H.C.;
RT "Novel Listeriaceae from food processing environments.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000519573, ECO:0000313|Proteomes:UP000529446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL L7-0051 {ECO:0000313|EMBL:MBC2294194.1,
RC ECO:0000313|Proteomes:UP000543005}, FSL L7-0054
RC {ECO:0000313|EMBL:MBC2284847.1, ECO:0000313|Proteomes:UP000585696},
RC FSL L7-0153 {ECO:0000313|EMBL:MBC2244852.1,
RC ECO:0000313|Proteomes:UP000550367}, FSL L7-0245
RC {ECO:0000313|EMBL:MBC2166293.1, ECO:0000313|Proteomes:UP000519573},
RC FSL L7-0360 {ECO:0000313|EMBL:MBC2115548.1,
RC ECO:0000313|Proteomes:UP000529446}, FSL L7-0435
RC {ECO:0000313|EMBL:MBC2002925.1, ECO:0000313|Proteomes:UP000546806},
RC FSL L7-0520 {ECO:0000313|EMBL:MBC1976209.1,
RC ECO:0000313|Proteomes:UP000587214}, FSL L7-0587
RC {ECO:0000313|EMBL:MBC2068806.1, ECO:0000313|Proteomes:UP000573524},
RC FSL L7-0729 {ECO:0000313|EMBL:MBC1945271.1,
RC ECO:0000313|Proteomes:UP000552349}, FSL L7-0811
RC {ECO:0000313|EMBL:MBC1912436.1, ECO:0000313|Proteomes:UP000574808},
RC FSL L7-0978 {ECO:0000313|EMBL:MBC1793036.1,
RC ECO:0000313|Proteomes:UP000539064}, FSL L7-1299
RC {ECO:0000313|EMBL:MBC1615943.1, ECO:0000313|Proteomes:UP000574104},
RC FSL L7-1385 {ECO:0000313|EMBL:MBC1575714.1,
RC ECO:0000313|Proteomes:UP000571880}, FSL L7-1387
RC {ECO:0000313|EMBL:MBC1561985.1, ECO:0000313|Proteomes:UP000541955},
RC FSL L7-1427 {ECO:0000313|EMBL:MBC1565740.1,
RC ECO:0000313|Proteomes:UP000586951}, FSL L7-1658
RC {ECO:0000313|EMBL:MBC1402375.1, ECO:0000313|Proteomes:UP000544413},
RC FSL L7-1816 {ECO:0000313|EMBL:MBC1317620.1,
RC ECO:0000313|Proteomes:UP000543379}, FSL L7-1825
RC {ECO:0000313|EMBL:MBC1309031.1, ECO:0000313|Proteomes:UP000571424},
RC FSL L7-1827 {ECO:0000313|EMBL:MBC1247164.1,
RC ECO:0000313|Proteomes:UP000574869}, and FSL L7-1833
RC {ECO:0000313|EMBL:MBC1333304.1, ECO:0000313|Proteomes:UP000532866};
RA Liao J., Wiedmann M.;
RT "Soil Listeria distribution.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Specifically dimethylates two adjacent adenosines (A1518 and
CC A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA
CC in the 30S particle. May play a critical role in biogenesis of 30S
CC subunits. {ECO:0000256|HAMAP-Rule:MF_00607}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-
CC methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-
CC dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:19609, Rhea:RHEA-COMP:10232, Rhea:RHEA-COMP:10233,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74493; EC=2.1.1.182;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00607};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00607}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. rRNA adenine N(6)-methyltransferase family. RsmA
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00607}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGL37601.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JNFA01000031; KGL37601.1; -; Genomic_DNA.
DR EMBL; JAAROQ010000005; MBC1247164.1; -; Genomic_DNA.
DR EMBL; JAAROS010000008; MBC1309031.1; -; Genomic_DNA.
DR EMBL; JAAROV010000003; MBC1317620.1; -; Genomic_DNA.
DR EMBL; JAAROL010000008; MBC1333304.1; -; Genomic_DNA.
DR EMBL; JAARPT010000007; MBC1402375.1; -; Genomic_DNA.
DR EMBL; JAARRW010000003; MBC1561985.1; -; Genomic_DNA.
DR EMBL; JAARRU010000003; MBC1565740.1; -; Genomic_DNA.
DR EMBL; JAARRX010000008; MBC1575714.1; -; Genomic_DNA.
DR EMBL; JAARSH010000004; MBC1615943.1; -; Genomic_DNA.
DR EMBL; JAARVG010000004; MBC1793036.1; -; Genomic_DNA.
DR EMBL; JAARWI010000003; MBC1912436.1; -; Genomic_DNA.
DR EMBL; JAASVH010000005; MBC1945271.1; -; Genomic_DNA.
DR EMBL; JAASWF010000009; MBC1976209.1; -; Genomic_DNA.
DR EMBL; JAARWW010000002; MBC2002925.1; -; Genomic_DNA.
DR EMBL; JAARWQ010000006; MBC2068806.1; -; Genomic_DNA.
DR EMBL; JAARXI010000001; MBC2115548.1; -; Genomic_DNA.
DR EMBL; JAARYH010000003; MBC2166293.1; -; Genomic_DNA.
DR EMBL; JAARYY010000007; MBC2244852.1; -; Genomic_DNA.
DR EMBL; JAARZS010000027; MBC2284847.1; -; Genomic_DNA.
DR EMBL; JAARZT010000027; MBC2294194.1; -; Genomic_DNA.
DR RefSeq; WP_036088362.1; NZ_UGPF01000001.1.
DR AlphaFoldDB; A0A099VYT5; -.
DR STRING; 1552123.EP57_16360; -.
DR GeneID; 58718904; -.
DR eggNOG; COG0030; Bacteria.
DR OrthoDB; 9814755at2; -.
DR Proteomes; UP000029844; Unassembled WGS sequence.
DR Proteomes; UP000519573; Unassembled WGS sequence.
DR Proteomes; UP000529446; Unassembled WGS sequence.
DR Proteomes; UP000532866; Unassembled WGS sequence.
DR Proteomes; UP000539064; Unassembled WGS sequence.
DR Proteomes; UP000541955; Unassembled WGS sequence.
DR Proteomes; UP000543005; Unassembled WGS sequence.
DR Proteomes; UP000543379; Unassembled WGS sequence.
DR Proteomes; UP000544413; Unassembled WGS sequence.
DR Proteomes; UP000546806; Unassembled WGS sequence.
DR Proteomes; UP000550367; Unassembled WGS sequence.
DR Proteomes; UP000552349; Unassembled WGS sequence.
DR Proteomes; UP000571424; Unassembled WGS sequence.
DR Proteomes; UP000571880; Unassembled WGS sequence.
DR Proteomes; UP000573524; Unassembled WGS sequence.
DR Proteomes; UP000574104; Unassembled WGS sequence.
DR Proteomes; UP000574808; Unassembled WGS sequence.
DR Proteomes; UP000574869; Unassembled WGS sequence.
DR Proteomes; UP000585696; Unassembled WGS sequence.
DR Proteomes; UP000586951; Unassembled WGS sequence.
DR Proteomes; UP000587214; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0052908; F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.8.100; Ribosomal RNA adenine dimethylase-like, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00607; 16SrRNA_methyltr_A; 1.
DR InterPro; IPR001737; KsgA/Erm.
DR InterPro; IPR023165; rRNA_Ade_diMease-like_C.
DR InterPro; IPR020596; rRNA_Ade_Mease_Trfase_CS.
DR InterPro; IPR020598; rRNA_Ade_methylase_Trfase_N.
DR InterPro; IPR011530; rRNA_adenine_dimethylase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00755; ksgA; 1.
DR PANTHER; PTHR11727; DIMETHYLADENOSINE TRANSFERASE; 1.
DR PANTHER; PTHR11727:SF7; DIMETHYLADENOSINE TRANSFERASE-RELATED; 1.
DR Pfam; PF00398; RrnaAD; 1.
DR SMART; SM00650; rADc; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01131; RRNA_A_DIMETH; 1.
DR PROSITE; PS51689; SAM_RNA_A_N6_MT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00607};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW Rule:MF_00607}; Reference proteome {ECO:0000313|Proteomes:UP000029844};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00607};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_00607};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_00607};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00607}.
FT DOMAIN 36..213
FT /note="Ribosomal RNA adenine methylase transferase N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00650"
FT BINDING 29
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00607,
FT ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 31
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00607,
FT ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 56
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00607,
FT ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 77
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00607,
FT ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 102
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00607,
FT ECO:0000256|PROSITE-ProRule:PRU01026"
FT BINDING 128
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00607,
FT ECO:0000256|PROSITE-ProRule:PRU01026"
SQ SEQUENCE 294 AA; 33470 MW; A56DB32DD6B40014 CRC64;
MNKDIATPGR TKEILKKYDF LFKKSLGQNF LIDSNILRRI TETAELDKDT DVIEIGPGIG
ALTEHLARTS KRVLAFEIDQ RLMSILPDTL AAYDNVEIVN EDILKVDVGE MIATKLPNRE
QPVKVVANLP YYVTTPIILQ LLHEDLPVSS MTFMLQKEVA DRISAKPGTK AYGSLSIAIQ
YYMEAELSFI VPKTVFMPQP NVDSAIIHLK RRQEPPAEVN NIDFFFDITR SSFAQRRKTL
WNNLVNRFPE LKAKKETLEP ALAELGIDVK RRGETLTIPE FAILSNFLDD FMRK
//