UniProt: A0A099W982

Database: UniProt
Entry: A0A099W982_9LIST

LinkDB:  A0A099W982_9LIST 
Original site:  A0A099W982_9LIST

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (30)   
   EMBL (30)   
Protein domain (5)   
   InterPro (4)   
   Pfam (1)   
All databases (42)   

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ID   A0A099W982_9LIST        Unreviewed;       193 AA.
AC   A0A099W982;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000256|HAMAP-Rule:MF_01031};
DE            EC=4.2.1.33 {ECO:0000256|HAMAP-Rule:MF_01031};
DE   AltName: Full=Alpha-IPM isomerase {ECO:0000256|HAMAP-Rule:MF_01031};
DE            Short=IPMI {ECO:0000256|HAMAP-Rule:MF_01031};
DE   AltName: Full=Isopropylmalate isomerase {ECO:0000256|HAMAP-Rule:MF_01031};
GN   Name=leuD {ECO:0000256|HAMAP-Rule:MF_01031,
GN   ECO:0000313|EMBL:KGL40690.1};
GN   ORFNames=EP57_09035 {ECO:0000313|EMBL:KGL40690.1}, HB759_02330
GN   {ECO:0000313|EMBL:MBC1330778.1}, HB809_02335
GN   {ECO:0000313|EMBL:MBC1306535.1}, HB810_03885
GN   {ECO:0000313|EMBL:MBC1245726.1}, HB818_03130
GN   {ECO:0000313|EMBL:MBC1284754.1}, HB900_03960
GN   {ECO:0000313|EMBL:MBC1573600.1}, HB902_01110
GN   {ECO:0000313|EMBL:MBC1560650.1}, HBP98_11080
GN   {ECO:0000313|EMBL:MBC2372543.1}, HCA46_03425
GN   {ECO:0000313|EMBL:MBC1777877.1}, HCA67_01075
GN   {ECO:0000313|EMBL:MBC2066343.1}, HCA68_05775
GN   {ECO:0000313|EMBL:MBC1897182.1}, HCA73_00535
GN   {ECO:0000313|EMBL:MBC1911116.1}, HCA78_09785
GN   {ECO:0000313|EMBL:MBC2004059.1}, HCA80_09825
GN   {ECO:0000313|EMBL:MBC2036521.1}, HCA81_02900
GN   {ECO:0000313|EMBL:MBC2019978.1}, HCB02_09205
GN   {ECO:0000313|EMBL:MBC2105129.1}, HCB06_05170
GN   {ECO:0000313|EMBL:MBC2116004.1}, HCB08_07120
GN   {ECO:0000313|EMBL:MBC2206595.1}, HCB25_01135
GN   {ECO:0000313|EMBL:MBC2242647.1}, HCB26_02350
GN   {ECO:0000313|EMBL:MBC2165417.1}, HCB29_07365
GN   {ECO:0000313|EMBL:MBC2162898.1}, HCB35_01115
GN   {ECO:0000313|EMBL:MBC2239058.1}, HCB69_00975
GN   {ECO:0000313|EMBL:MBC2282946.1}, HCB83_02315
GN   {ECO:0000313|EMBL:MBC2303686.1}, HCC18_01050
GN   {ECO:0000313|EMBL:MBC2315416.1}, HCC36_02170
GN   {ECO:0000313|EMBL:MBC2292025.1}, HCI99_00550
GN   {ECO:0000313|EMBL:MBC1490308.1}, HCJ32_04815
GN   {ECO:0000313|EMBL:MBC1944282.1}, HCJ43_12795
GN   {ECO:0000313|EMBL:MBC1976152.1}, HCJ81_03175
GN   {ECO:0000313|EMBL:MBC2309871.1};
OS   Listeria booriae.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=1552123 {ECO:0000313|EMBL:KGL40690.1, ECO:0000313|Proteomes:UP000029844};
RN   [1] {ECO:0000313|EMBL:KGL40690.1, ECO:0000313|Proteomes:UP000029844}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSL A5-0281 {ECO:0000313|EMBL:KGL40690.1,
RC   ECO:0000313|Proteomes:UP000029844};
RA   den Bakker H.C.;
RT   "Novel Listeriaceae from food processing environments.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000519573, ECO:0000313|Proteomes:UP000526161}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSL L7-0029 {ECO:0000313|EMBL:MBC2315416.1,
RC   ECO:0000313|Proteomes:UP000576477}, FSL L7-0035
RC   {ECO:0000313|EMBL:MBC2303686.1, ECO:0000313|Proteomes:UP000526161},
RC   FSL L7-0039 {ECO:0000313|EMBL:MBC2309871.1,
RC   ECO:0000313|Proteomes:UP000565628}, FSL L7-0051
RC   {ECO:0000313|EMBL:MBC2292025.1, ECO:0000313|Proteomes:UP000543005},
RC   FSL L7-0054 {ECO:0000313|EMBL:MBC2282946.1,
RC   ECO:0000313|Proteomes:UP000585696}, FSL L7-0149
RC   {ECO:0000313|EMBL:MBC2239058.1, ECO:0000313|Proteomes:UP000553016},
RC   FSL L7-0153 {ECO:0000313|EMBL:MBC2242647.1,
RC   ECO:0000313|Proteomes:UP000550367}, FSL L7-0217
RC   {ECO:0000313|EMBL:MBC2206595.1, ECO:0000313|Proteomes:UP000572892},
RC   FSL L7-0245 {ECO:0000313|EMBL:MBC2165417.1,
RC   ECO:0000313|Proteomes:UP000519573}, FSL L7-0256
RC   {ECO:0000313|EMBL:MBC2162898.1, ECO:0000313|Proteomes:UP000528739},
RC   FSL L7-0335 {ECO:0000313|EMBL:MBC2105129.1,
RC   ECO:0000313|Proteomes:UP000565263}, FSL L7-0360
RC   {ECO:0000313|EMBL:MBC2116004.1, ECO:0000313|Proteomes:UP000529446},
RC   FSL L7-0385 {ECO:0000313|EMBL:MBC2019978.1,
RC   ECO:0000313|Proteomes:UP000587422}, FSL L7-0435
RC   {ECO:0000313|EMBL:MBC2004059.1, ECO:0000313|Proteomes:UP000546806},
RC   FSL L7-0459 {ECO:0000313|EMBL:MBC2036521.1,
RC   ECO:0000313|Proteomes:UP000591514}, FSL L7-0520
RC   {ECO:0000313|EMBL:MBC1976152.1, ECO:0000313|Proteomes:UP000587214},
RC   FSL L7-0587 {ECO:0000313|EMBL:MBC2066343.1,
RC   ECO:0000313|Proteomes:UP000573524}, FSL L7-0729
RC   {ECO:0000313|EMBL:MBC1944282.1, ECO:0000313|Proteomes:UP000552349},
RC   FSL L7-0811 {ECO:0000313|EMBL:MBC1911116.1,
RC   ECO:0000313|Proteomes:UP000574808}, FSL L7-0818
RC   {ECO:0000313|EMBL:MBC1897182.1, ECO:0000313|Proteomes:UP000578190},
RC   FSL L7-1017 {ECO:0000313|EMBL:MBC1777877.1,
RC   ECO:0000313|Proteomes:UP000547643}, FSL L7-1385
RC   {ECO:0000313|EMBL:MBC1573600.1, ECO:0000313|Proteomes:UP000571880},
RC   FSL L7-1387 {ECO:0000313|EMBL:MBC1560650.1,
RC   ECO:0000313|Proteomes:UP000541955}, FSL L7-1547
RC   {ECO:0000313|EMBL:MBC1490308.1, ECO:0000313|Proteomes:UP000533953},
RC   FSL L7-1825 {ECO:0000313|EMBL:MBC1306535.1,
RC   ECO:0000313|Proteomes:UP000571424}, FSL L7-1827
RC   {ECO:0000313|EMBL:MBC1245726.1, ECO:0000313|Proteomes:UP000574869},
RC   FSL L7-1833 {ECO:0000313|EMBL:MBC1330778.1,
RC   ECO:0000313|Proteomes:UP000532866}, FSL L7-1836
RC   {ECO:0000313|EMBL:MBC1284754.1, ECO:0000313|Proteomes:UP000588455},
RC   and FSL L7-1850 {ECO:0000313|EMBL:MBC2372543.1,
RC   ECO:0000313|Proteomes:UP000546244};
RA   Liao J., Wiedmann M.;
RT   "Soil Listeria distribution.";
RL   Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the isomerization between 2-isopropylmalate and 3-
CC       isopropylmalate, via the formation of 2-isopropylmaleate.
CC       {ECO:0000256|ARBA:ARBA00002695, ECO:0000256|HAMAP-Rule:MF_01031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate;
CC         Xref=Rhea:RHEA:32287, ChEBI:CHEBI:1178, ChEBI:CHEBI:35121;
CC         EC=4.2.1.33; Evidence={ECO:0000256|ARBA:ARBA00000491,
CC         ECO:0000256|HAMAP-Rule:MF_01031};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine
CC       from 3-methyl-2-oxobutanoate: step 2/4. {ECO:0000256|ARBA:ARBA00004729,
CC       ECO:0000256|HAMAP-Rule:MF_01031}.
CC   -!- SUBUNIT: Heterodimer of LeuC and LeuD. {ECO:0000256|ARBA:ARBA00011271,
CC       ECO:0000256|HAMAP-Rule:MF_01031}.
CC   -!- SIMILARITY: Belongs to the LeuD family. LeuD type 1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009845, ECO:0000256|HAMAP-Rule:MF_01031}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGL40690.1}.
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DR   EMBL; JNFA01000023; KGL40690.1; -; Genomic_DNA.
DR   EMBL; JAAROQ010000001; MBC1245726.1; -; Genomic_DNA.
DR   EMBL; JAAROI010000001; MBC1284754.1; -; Genomic_DNA.
DR   EMBL; JAAROS010000001; MBC1306535.1; -; Genomic_DNA.
DR   EMBL; JAAROL010000001; MBC1330778.1; -; Genomic_DNA.
DR   EMBL; JAASTX010000001; MBC1490308.1; -; Genomic_DNA.
DR   EMBL; JAARRW010000001; MBC1560650.1; -; Genomic_DNA.
DR   EMBL; JAARRX010000002; MBC1573600.1; -; Genomic_DNA.
DR   EMBL; JAARUV010000001; MBC1777877.1; -; Genomic_DNA.
DR   EMBL; JAARWF010000002; MBC1897182.1; -; Genomic_DNA.
DR   EMBL; JAARWI010000001; MBC1911116.1; -; Genomic_DNA.
DR   EMBL; JAASVH010000002; MBC1944282.1; -; Genomic_DNA.
DR   EMBL; JAASWF010000008; MBC1976152.1; -; Genomic_DNA.
DR   EMBL; JAARWW010000004; MBC2004059.1; -; Genomic_DNA.
DR   EMBL; JAARWY010000001; MBC2019978.1; -; Genomic_DNA.
DR   EMBL; JAARWV010000004; MBC2036521.1; -; Genomic_DNA.
DR   EMBL; JAARWQ010000001; MBC2066343.1; -; Genomic_DNA.
DR   EMBL; JAARXL010000004; MBC2105129.1; -; Genomic_DNA.
DR   EMBL; JAARXI010000002; MBC2116004.1; -; Genomic_DNA.
DR   EMBL; JAARYE010000002; MBC2162898.1; -; Genomic_DNA.
DR   EMBL; JAARYH010000001; MBC2165417.1; -; Genomic_DNA.
DR   EMBL; JAARYN010000002; MBC2206595.1; -; Genomic_DNA.
DR   EMBL; JAARZA010000001; MBC2239058.1; -; Genomic_DNA.
DR   EMBL; JAARYY010000001; MBC2242647.1; -; Genomic_DNA.
DR   EMBL; JAARZS010000002; MBC2282946.1; -; Genomic_DNA.
DR   EMBL; JAARZT010000003; MBC2292025.1; -; Genomic_DNA.
DR   EMBL; JAARZW010000002; MBC2303686.1; -; Genomic_DNA.
DR   EMBL; JAASWV010000003; MBC2309871.1; -; Genomic_DNA.
DR   EMBL; JAARZZ010000001; MBC2315416.1; -; Genomic_DNA.
DR   EMBL; JAARMV010000002; MBC2372543.1; -; Genomic_DNA.
DR   RefSeq; WP_036085896.1; NZ_UGPF01000002.1.
DR   STRING; 1552123.EP57_09035; -.
DR   GeneID; 58717516; -.
DR   eggNOG; COG0066; Bacteria.
DR   OrthoDB; 9777465at2; -.
DR   UniPathway; UPA00048; UER00071.
DR   Proteomes; UP000029844; Unassembled WGS sequence.
DR   Proteomes; UP000519573; Unassembled WGS sequence.
DR   Proteomes; UP000526161; Unassembled WGS sequence.
DR   Proteomes; UP000528739; Unassembled WGS sequence.
DR   Proteomes; UP000529446; Unassembled WGS sequence.
DR   Proteomes; UP000532866; Unassembled WGS sequence.
DR   Proteomes; UP000533953; Unassembled WGS sequence.
DR   Proteomes; UP000541955; Unassembled WGS sequence.
DR   Proteomes; UP000543005; Unassembled WGS sequence.
DR   Proteomes; UP000546244; Unassembled WGS sequence.
DR   Proteomes; UP000546806; Unassembled WGS sequence.
DR   Proteomes; UP000547643; Unassembled WGS sequence.
DR   Proteomes; UP000550367; Unassembled WGS sequence.
DR   Proteomes; UP000552349; Unassembled WGS sequence.
DR   Proteomes; UP000553016; Unassembled WGS sequence.
DR   Proteomes; UP000565263; Unassembled WGS sequence.
DR   Proteomes; UP000565628; Unassembled WGS sequence.
DR   Proteomes; UP000571424; Unassembled WGS sequence.
DR   Proteomes; UP000571880; Unassembled WGS sequence.
DR   Proteomes; UP000572892; Unassembled WGS sequence.
DR   Proteomes; UP000573524; Unassembled WGS sequence.
DR   Proteomes; UP000574808; Unassembled WGS sequence.
DR   Proteomes; UP000574869; Unassembled WGS sequence.
DR   Proteomes; UP000576477; Unassembled WGS sequence.
DR   Proteomes; UP000578190; Unassembled WGS sequence.
DR   Proteomes; UP000585696; Unassembled WGS sequence.
DR   Proteomes; UP000587214; Unassembled WGS sequence.
DR   Proteomes; UP000587422; Unassembled WGS sequence.
DR   Proteomes; UP000588455; Unassembled WGS sequence.
DR   Proteomes; UP000591514; Unassembled WGS sequence.
DR   GO; GO:0009316; C:3-isopropylmalate dehydratase complex; IEA:InterPro.
DR   GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01577; IPMI_Swivel; 1.
DR   Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR   HAMAP; MF_01031; LeuD_type1; 1.
DR   InterPro; IPR004431; 3-IsopropMal_deHydase_ssu.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   InterPro; IPR033940; IPMI_Swivel.
DR   NCBIfam; TIGR00171; leuD; 1.
DR   PANTHER; PTHR43345:SF5; 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT; 1.
DR   PANTHER; PTHR43345; 3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605, ECO:0000256|HAMAP-
KW   Rule:MF_01031};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304,
KW   ECO:0000256|HAMAP-Rule:MF_01031}; Isomerase {ECO:0000313|EMBL:KGL40690.1};
KW   Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430, ECO:0000256|HAMAP-
KW   Rule:MF_01031};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01031};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029844}.
FT   DOMAIN          2..123
FT                   /note="Aconitase A/isopropylmalate dehydratase small
FT                   subunit swivel"
FT                   /evidence="ECO:0000259|Pfam:PF00694"
SQ   SEQUENCE   193 AA;  22059 MW;  AB6E4377B12A2A3B CRC64;
     MEAMVLHKGR TVALMNDNID TDQIIPKQFL KRIERTGFGE FLFDEWRYLP DRSLNPDFPL
     NAPDRQEATI LITGENFGCG SSREHAPWAL LDYRFRIIIA GGYSDIFYMN CTKNGILPIS
     LPKEAREKLA TIPASEEIAV DLPKQQVISS VGTYDFEIDA TWKEKFMKGL DDIAQTMEHE
     AMITAYENQA RAY
//

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