ID A0A099YUQ5_TINGU Unreviewed; 1229 AA.
AC A0A099YUQ5;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 03-MAY-2023, entry version 26.
DE SubName: Full=DENN domain-containing protein 5A {ECO:0000313|EMBL:KGL73071.1};
DE Flags: Fragment;
GN ORFNames=N309_09600 {ECO:0000313|EMBL:KGL73071.1};
OS Tinamus guttatus (White-throated tinamou).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL73071.1, ECO:0000313|Proteomes:UP000053641};
RN [1] {ECO:0000313|EMBL:KGL73071.1, ECO:0000313|Proteomes:UP000053641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL73071.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; KL885556; KGL73071.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099YUQ5; -.
DR STRING; 94827.A0A099YUQ5; -.
DR Proteomes; UP000053641; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17690; RUN1_DENND5A; 1.
DR CDD; cd17692; RUN2_DENND5A; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047294; RUN1_DENND5A.
DR InterPro; IPR047295; RUN2_DENND5A.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053641};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..539
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 729..892
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 896..1004
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1076..1224
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 623..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL73071.1"
FT NON_TER 1229
FT /evidence="ECO:0000313|EMBL:KGL73071.1"
SQ SEQUENCE 1229 AA; 140946 MW; CF6FD49078ABF9C0 CRC64;
TGENFEQTPL RRTFKSKVLA RYPENVEWNP FDQDAVGMLC MPKGLAFKTQ ADSREPQFHS
FIITREDGSR TFGFSLTFFE EVTSKQICSA MQTLYHMHNA EYDIFHTPPP NDRDSCSSTG
DCNGTSVSKL QRFNSYDISR DTLYVSKCIC LIAPMSFMKA CKKVLEQLYQ AVTSPQPPPL
PLESYIYNIL YEVPLPPAGR SLKFSGVYGP IICQRPSTNE LPLFDFPVKE VFELLGVENV
VQLFTCALLE FQILLYSQHY QRLMTVAETI TALMFPFQWQ HVYVPILPAS LLHFLDAPVP
YLMGLHSNGL DDRSKLELPQ EANLCFVDVD NHFIELPEDL PQFPNKLEFI QEISEILMTF
GIPPEGNLHC SESASKMKSL RACDIVSDKR NGNIAGSPLN SCELLKENET IARLQALVKR
TGVSLEKLEV REETSSKKDL KIQCDEEEFK IYQLNIQIRE VFANRFTQMF ADYEVFVIQP
SQDKESWFTN REQMQNFDKA SFLSDQPEPY LPFLSRFLET QMFASFIDNK IMCHDEDEKD
PVLRVFDSRV DKIRLLNVRT PTLRTSMYQK CTTIDEAEKA IELRLAKIDH TAVHPHLLDM
KIGQGKYELG FFPKLQSDVL STGPASNKWT KRNAPAQWRR KDRQKQHTEH LRLDNDQREK
YIQEARNLGS TIRQPKLSNL SPSVIAQTNC KFVEGLLKEC RNKTKRMLVE KMGREAVELG
HGEVNITGVE ENTLIASLCD LLERIWSHGL QVKQGKSALW SHLLHYLENR QRRATSGSFS
SSGILLDSER RKSDASPAMS PLRISLVQDM RHIQNISEIK TDVGKARAWV RLSMEKKLLS
RHLKQLLSDH ELTKKLYKRY AFLRCDDEKE QFLYHLLSFN AVDYFCFTNV FTTVLIPYHI
LIVPSKKLGG SMFTANPWIC ISGELGETGI LQVPRNILEM TFECQNLGKL TTVQIGHDNS
GLYAKWLVEY VMVRNEITGH TYKFPCGRWL GKGMDDGSLE RILVGELLTS HMEADERQCR
TPPLQQSPSM IRRLVAISPN NKPKLNTGQI QEAIGEAVNG IVKHFHKPEK ERGSLTLLLC
GESGLVSALE QVFQHGFKSP RLFKNVFIWD FLEKAQTYYE TLEQNEMVSE ENWQTRARNF
CRFITAINNT PRNIGKDGKF QMLVCLGARD HLLHHWIALL ADCPITAQMY EEVALIKDHT
LVNSLIRVLQ TLQEFNITLE ASLVKGIDI
//
