ID A0A099YZI5_TINGU Unreviewed; 791 AA.
AC A0A099YZI5;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Ras GTPase-activating protein 2 {ECO:0000313|EMBL:KGL73925.1};
DE Flags: Fragment;
GN ORFNames=N309_03416 {ECO:0000313|EMBL:KGL73925.1};
OS Tinamus guttatus (White-throated tinamou).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL73925.1, ECO:0000313|Proteomes:UP000053641};
RN [1] {ECO:0000313|EMBL:KGL73925.1, ECO:0000313|Proteomes:UP000053641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL73925.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL886535; KGL73925.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099YZI5; -.
DR STRING; 94827.A0A099YZI5; -.
DR Proteomes; UP000053641; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd13370; PH_GAP1m_mammal-like; 1.
DR CDD; cd05394; RasGAP_RASA2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037773; RASA2_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF21; RAS GTPASE-ACTIVATING PROTEIN 2; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053641};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..89
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 100..240
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 306..500
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 555..656
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL73925.1"
FT NON_TER 791
FT /evidence="ECO:0000313|EMBL:KGL73925.1"
SQ SEQUENCE 791 AA; 91175 MW; CC7F95A8081F2D55 CRC64;
EAKHLVPNKM RDVFCTINLD QEEVFRTQVV EKSLSPYFGE EFYFEIPRTF QWLSFYIYDK
SVLQKDLRIG KVSIKKDDLC NYTGKESWFL LQPIDSNSEV QGKVHLELKL NELITDNGSV
CQQLVVHIKE CHGLPLINGQ NCDPYATVSL VGPSRNDQKK TKVKKKTSNP QFNETFYFEV
TRSSSYTKKS QFQVEEEDIE KLEVRVDLWN NGNLVQDIFL GEIKVPVKVL RNDSFQAWYL
LQPRENGNKS SKTDDLGSLR LNICYTEDYV LPSEYYASLR NLLLKSSDVQ PISASAAYIL
SEVCRDKYDA VLPLVRLLLH HNKLVPFVTA VAELDLKDTQ EANTVFRGNT LATRCVDEMM
KIVGRHYLKV TLKPVLDEIC ESPKPCEIDP IKLKEGDNVE IHMENLRYYV DKVFREIVRS
SISCPTLMCD VFYSLRHLAA KRFPNDPHVQ YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP
DAQTSRTLTL ISKAIQTLGS WGSLTKSKLS SFKETFMYEF FKTFQEEKFT ESVKKFLDDV
SSTESKEPSG LSEPVHLKEG EMYKRAQGRT RIGKKNFKKR WFCLTSREFT YHKQQDKEPI
FTIPIKNILA VEKLDESSFN KKNMFQVLHG EKPLYIQANN CVEASEWIEA LCRVTRCNQK
RLNFYHPSAF LNGNWLCCKA TIENTEGCAR CTADVPADTQ IEIDGDRETE RIYSLFTINI
SKLQKLEEAC GSIAVYQGPQ KEPDDYSSFT IEDSVATFHT LKQIIDIVEK LNDSHEKYQK
KRSSSAKYGS E
//
