ID   A0A099ZG65_TINGU        Unreviewed;       719 AA.
AC   A0A099ZG65;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Solute carrier family 12 member 8 {ECO:0000313|EMBL:KGL79820.1};
DE   Flags: Fragment;
GN   ORFNames=N309_05992 {ECO:0000313|EMBL:KGL79820.1};
OS   Tinamus guttatus (White-throated tinamou).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX   NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL79820.1, ECO:0000313|Proteomes:UP000053641};
RN   [1] {ECO:0000313|EMBL:KGL79820.1, ECO:0000313|Proteomes:UP000053641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL79820.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   EMBL; KL892454; KGL79820.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A099ZG65; -.
DR   STRING; 94827.A0A099ZG65; -.
DR   Proteomes; UP000053641; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF6; SOLUTE CARRIER FAMILY 12 MEMBER 8; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053641};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        70..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        147..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        183..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        306..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        604..636
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        642..661
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          44..410
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   REGION          502..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..560
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KGL79820.1"
FT   NON_TER         719
FT                   /evidence="ECO:0000313|EMBL:KGL79820.1"
SQ   SEQUENCE   719 AA;  78789 MW;  C5CD6FB409340829 CRC64;
     RSEAYVQDLF HEEAQQVPQT QTKPWWKIQL FVWEPVLFGT WDGVFTSCMI NIFGVVLFLR
     TGWLVGNTGI LMGMFLVSFV VLVALVTVLS GIGVCERCSI GSGGVYSMIS TVLGGQVGGT
     IGLLYIFGQC VAGAMYITGF AESIADVVGL SNIWAVRGIS LAVLLGLLGI NLAGVKWIIR
     LQLLLLFLLA VSTLDFVIGS FTHLDPEHGF VGYSEELMSN NTLPDYSQGE SFFTVFGVFF
     PAATGVMAGF NMSGDLQKPA TNIPLGSLAA IGTSWFLYMV FVFLLGAVCT RQSLRYDFMI
     AEKVSLVGFL FLLGLYISSL ASCMGGLYGA PRILQCIAQE NVIPVFAFLG RGRGPNKTPV
     AAICLTSLIT MAFVFIGQVN VLAPIVTIIF MLTYIAVDYS YFSVSLTYNI LQKPEKMQME
     NLRPAHSSQP LILNKPSAYG SDGIIHSRSN GTLLEFTRDM DQLFKPFHNE PVTCEKKEAA
     ENLTQKVKQR KLKKPAKQTL QDSFLLDLEP GAGPAHYSRE EPVPLGAEGP AEQIPPREGA
     LFGSERDPPR SERGEGGERL PEETQVLPGQ RAEDSAVKQQ NPELGIQQIP VSFYSKFCNH
     WVSFAGAIVS LLIMFVIQWI YTLISLGAAV ILYFYIGRVS PGLPLGAAAN FSLFSWIKLL
     LVTSCRRRPS PEEHFVVTPS FATVGVETTQ LTEENADFAA RGRYHRSSVI SRADFGNQF
//