ID A0A099ZH98_TINGU Unreviewed; 837 AA.
AC A0A099ZH98;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Rho GTPase-activating protein 12 {ECO:0000313|EMBL:KGL81754.1};
DE Flags: Fragment;
GN ORFNames=N309_00662 {ECO:0000313|EMBL:KGL81754.1};
OS Tinamus guttatus (White-throated tinamou).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL81754.1, ECO:0000313|Proteomes:UP000053641};
RN [1] {ECO:0000313|EMBL:KGL81754.1, ECO:0000313|Proteomes:UP000053641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL81754.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL894504; KGL81754.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099ZH98; -.
DR STRING; 94827.A0A099ZH98; -.
DR Proteomes; UP000053641; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12070; SH3_ARHGAP12; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035491; ARHGAP12_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF107; RHO GTPASE-ACTIVATING PROTEIN 12; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16618; SH3-WW_linker; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053641};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..73
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 261..294
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 360..387
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 454..566
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 647..835
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 194..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL81754.1"
FT NON_TER 837
FT /evidence="ECO:0000313|EMBL:KGL81754.1"
SQ SEQUENCE 837 AA; 95339 MW; EC635BC236A9793E CRC64;
EMADKGVKIL PGQLYIEVEY DYEYEAKDKK IVIKQGEKYI LVKKTNDDWW QVKRDENSKP
FYVPAQYVKE IPRKALMPPI KPAGMLPNSA LKMTHGLQRS TENVNKLPEL SSFGKSSPVQ
VSCLVRDANQ NLGPNNSPSQ TFGLSLDLTQ NNEKLNNDLQ SPKISNQYRA LSVGHFPCPE
FLEIEKTSFL HEQSCDSAGE GSEKIHQDSE SGDELSSSST EQVQPTTPPS QGRPDSPVYA
NLQELKISQS ALPPLPTSAP VQINGEWETH KDTTGRYYYY NRGTQERTWK PPRWARDASI
NKGDSQSHAD HEPLSSEEND HSSCYSQSDS QYGSPPKGWS EELDEHGQTL YTNDYTNEKW
IKHADEQGRP YYYSADGSRS EWELPRYNAS PQQQRDIIKS RSLDRRLQEP IVLTKWRHST
IVLDTNDKEL STASKASFPE NESSPSSPKH QATGQEKYGL LNVTKITDNG KKVRKNWTSS
WAVLQGSSLL FTKTQGSGTG WFGVNQSKPE FTVDLKGALI DWASKDKSSK KNVIELKTRQ
GTELLIQSDN DSFINEWYKV LNYTINNQVV ESDEALEDEI PDSPGVEKQD KEKENKDSKK
LRLKVPSNID STEQKKTKTK LKKFLTRRPT LQAVREKGYI KDQVFGSNLT SLCQRENSTV
PKFVKLCIEH VEEHGLDVDG LYRVSGNLAV IQKLRFAVNH DEKLDLNDSK WEDIHVITGA
LKMFFRELPE PLFTYNHFND FVNAIKQEPR QRVHAVKDLI KQLPKPNQDT MQVLFRHLKR
VVENGEKNRM TYQSVAIVFG PTLLKPEKET GNIAVHTVYQ NQIVELILLE LNSVFGR
//