ID A0A099ZN73_TINGU Unreviewed; 919 AA.
AC A0A099ZN73;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
DE Flags: Fragment;
GN ORFNames=N309_12233 {ECO:0000313|EMBL:KGL82368.1};
OS Tinamus guttatus (White-throated tinamou).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Tinamiformes; Tinamidae; Tinamus.
OX NCBI_TaxID=94827 {ECO:0000313|EMBL:KGL82368.1, ECO:0000313|Proteomes:UP000053641};
RN [1] {ECO:0000313|EMBL:KGL82368.1, ECO:0000313|Proteomes:UP000053641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N309 {ECO:0000313|EMBL:KGL82368.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; KL895143; KGL82368.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A099ZN73; -.
DR STRING; 94827.A0A099ZN73; -.
DR Proteomes; UP000053641; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08801; Death_UNC5D; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR042058; UNC5D_Death.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000053641};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 346..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 132..210
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 508..648
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL82368.1"
FT NON_TER 919
FT /evidence="ECO:0000313|EMBL:KGL82368.1"
SQ SEQUENCE 919 AA; 102196 MW; DA5ECF3CAA4E1E3F CRC64;
GNDNSEALPE SIPSAPGTLP HFMEEPDDAY IIKSNPIVLR CKAMPAMQIF FKCNGEWVHQ
NEHVSEESMD EATGLKVREV FINVTRQQVE DFHGPEDYWC QCVAWSHLGT SKSRKAAVRI
AYLRKNFEQD PQGKEVPIEG MIVLHCRPPE GVPAAEVEWL KNEEPIDSNL DENIDTRADH
NLIIRQARLS DSGNYTCMAA NIVARRRSLS ATVVVYVNGG WSSWTEWSSC NARCGRGWQK
RSRTCTNPAP LNGGAFCEGM SVQKITCTSL CPVDGNWEVW SEWSVCSPEC EHLRVRECVA
PPPRNGGKYC EGSSQESENC TEGLCIQDKK PLHEIKSQNM ENASDIALYS GLGAAVIAVA
VLVVAVTLYR RSQSEYGVDV IDSSALTGGF QTFNFKTVRQ GNSLLLNSSM QPDLTVSRTY
SGPICLQDPL DKELMTESSL FNPLSDIKVK VQSSFMVSLG VTERAEYHSK AHSGTFPHGN
NRGFGTIHGR NKATYIQNLC PITTKSDLKT TAVFGHLGGR LVIPNTGVSL LIPHGAIPEE
SSWEIYLAIA QRESSLQPDG PDVLLGPEVS CGPSDVSVST PFALTIPHCA ELNSEHWNIH
LKRRTQQGKW EEVMSVEEET TSCYCLLDPY ACHILLNSFG TYALIGEPIS DCAVRQLKVA
VFGCMSCNSL DYNLRVYCMD NTPCAFQEVV SDEKLQGGQL LEEPKLLHFR GNTFSLQISV
LDIPPFLWRI KPFTACQEVP FSRVWGSNQA PLHCAFSLER YTPATTQLSC KICVRQLKGH
EQVLQIHTSI LENERETVTF FAHDDSNFPA QMGPKAFKIP YSIRQRICAT FDTPSAKGKD
WQMLAQKNSI NRNLSYFATQ SSPSAVILDL WEARHQHDGD LDSLACALEE IGRTHSKISN
IAETEVEEPD FSYSRQNGL
//
