ID A0A0A0A2S1_CHAVO Unreviewed; 125 AA.
AC A0A0A0A2S1;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 28-JUN-2023, entry version 25.
DE SubName: Full=Islet amyloid polypeptide {ECO:0000313|EMBL:KGL88869.1};
GN ORFNames=N301_16212 {ECO:0000313|EMBL:KGL88869.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL88869.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL88869.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL88869.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calcitonin family.
CC {ECO:0000256|ARBA:ARBA00009222}.
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DR EMBL; KL870627; KGL88869.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0A2S1; -.
DR STRING; 50402.A0A0A0A2S1; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.2190; -; 1.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR InterPro; IPR000443; IAPP.
DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR PANTHER; PTHR10505:SF4; ISLET AMYLOID POLYPEPTIDE; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00818; ISLETAMYLOID.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..125
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001966715"
FT DOMAIN 77..119
FT /note="Calcitonin peptide-like"
FT /evidence="ECO:0000259|SMART:SM00113"
FT DISULFID 80..85
FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ SEQUENCE 125 AA; 13461 MW; 072462FC1898E76F CRC64;
MCNLKLSVFF IALSVTLSCL EATPIEKLLS VADDLADGTS KRQGWILPVM SQNTLSGLSG
EMPEQPSAKT KSHHLEKRKC NTATCVTQRL ADFLVRSSNN IGAIYSPTNV GSNTYGKRDT
AGLLS
//
