ID A0A0A0A9I3_CHAVO Unreviewed; 1006 AA.
AC A0A0A0A9I3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Connector enhancer of kinase suppressor of ras 2 {ECO:0000313|EMBL:KGL90602.1};
DE Flags: Fragment;
GN ORFNames=N301_11186 {ECO:0000313|EMBL:KGL90602.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL90602.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL90602.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL90602.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR EMBL; KL871140; KGL90602.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0A9I3; -.
DR STRING; 50402.A0A0A0A9I3; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01260; PH_CNK_mammalian-like; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR010599; CNK2/3_dom.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF12; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2; 1.
DR Pfam; PF06663; CNK2_3_dom; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:KGL90602.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW Transferase {ECO:0000313|EMBL:KGL90602.1}.
FT DOMAIN 1..55
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 63..157
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 194..276
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 545..644
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 390..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL90602.1"
FT NON_TER 1006
FT /evidence="ECO:0000313|EMBL:KGL90602.1"
SQ SEQUENCE 1006 AA; 113924 MW; 67F2D92C985CB782 CRC64;
GLDDCLQQYI KNFEKEKING EQLLHITHQE LEELGVTRIG HQELILEAVD LLCALNYGLE
TENLRTLSHK LNASAKNLQN FITGRRRSGH YDGRASRRLP NDFLTSVVDL IGAAKNLLAW
LDRSPFVSVT EYSLLKNNIV QLCLELTTIV QQDCTVYETE NKILHVCKTL SGICDHIISL
SSDSLVSQSA HLEVVHLTSI MPSEGLGMYI KSTYDGLHVI TGTTENSPAD QCKKIHAGDE
VIQVNHQTVV GWQLKNLVNA LREDPNGVIL TLKKRPQNTL VSAPALLKNV RWKPLALQPV
IPTSPTSSST TPTSTMGISS KMENSALQDV FILSPMSGLY GPRDEIGIMS CDDISKFGKP
GMKGSESPNY FLEHESGKYY TLIEGEGHPV GSEYERSRAT GVRRREKTPT HGDLRPVSMP
TEYSWIGESK EQNMYKRGSR DSENSLLRYL SDDKILVIQE EPLTQKDNKR DTGRRSRKKG
KNTSSPNYPI SPPVLTSTIN ARLEPGQQDV LNFSLAENNT VPLYHVRSSL TSGSRRRISC
KDLGHGDCEG WLWKKKDAKG YFTQKWKKYW FILKDSSLYW YTNQNDEKAE GFISLPEFRI
DRAIECRRKH AFKACHPKIK SFYFATDCLE EMNRWMNRLG LAAIGYTPDD KEMHPDEDYW
SESDQDDIDG SLTLKQEGSA TLCDTYHRTP SVNSSSPFPE AKHGRHFSSE STYSHSSAED
SRQDVAGSTH SSGCRPPYRE RRSWQDLIET PLTSSGLHFL QTVPPDTEYM SGRSGMSPDK
RRQATLPVQR RHNYEQDGPF PLVECQRGHS SYSRPQKQRS QSLPRNRDVR GKGCVQSIEG
TDDKLEEKVP IRRHNSFCVE GFFIYFLSEN VKEIGENTDG LQELYKSLEQ ASLSAFGEQR
PSTKQEFRRS FVKRCNDPVI NEKLHHIRVL KSTLKAKEGD LTVINSLLDD PNLTSKKFKD
WKLKNYEFFL DICEYSAAVK SQNGASELAT SAPMLTHTHS FIETHV
//
