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Database: UniProt
Entry: A0A0A0A9Q1_CHAVO
LinkDB: A0A0A0A9Q1_CHAVO
Original site: A0A0A0A9Q1_CHAVO 
ID   A0A0A0A9Q1_CHAVO        Unreviewed;      1249 AA.
AC   A0A0A0A9Q1;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Apoptotic protease-activating factor 1 {ECO:0000256|PIRNR:PIRNR037646};
DE            Short=APAF-1 {ECO:0000256|PIRNR:PIRNR037646};
GN   ORFNames=N301_14697 {ECO:0000313|EMBL:KGL91299.1};
OS   Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX   NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL91299.1, ECO:0000313|Proteomes:UP000053858};
RN   [1] {ECO:0000313|EMBL:KGL91299.1, ECO:0000313|Proteomes:UP000053858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL91299.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent
CC       autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the
CC       activation of caspase-3 and apoptosis. This activation requires ATP.
CC       {ECO:0000256|PIRNR:PIRNR037646}.
CC   -!- SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
CC       {ECO:0000256|PIRNR:PIRNR037646}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}.
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DR   EMBL; KL871235; KGL91299.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A0A9Q1; -.
DR   STRING; 50402.A0A0A0A9Q1; -.
DR   Proteomes; UP000053858; Unassembled WGS sequence.
DR   GO; GO:0043293; C:apoptosome; IEA:InterPro.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd08323; CARD_APAF1; 1.
DR   CDD; cd00200; WD40; 2.
DR   Gene3D; 1.25.40.370; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR017251; Apaf-1.
DR   InterPro; IPR041452; APAF1_C.
DR   InterPro; IPR037963; APAF1_CARD_dom.
DR   InterPro; IPR048975; APAF1_WHD.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   Pfam; PF21296; APAF-1-like_WHD; 1.
DR   Pfam; PF17908; APAF1_C; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF00400; WD40; 10.
DR   PIRSF; PIRSF037646; Apop_pept_activating-1; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 13.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 9.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PIRNR:PIRNR037646};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR037646};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR037646};
KW   Hydrolase {ECO:0000313|EMBL:KGL91299.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037646};
KW   Protease {ECO:0000313|EMBL:KGL91299.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          1..90
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   REPEAT          609..650
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          651..692
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          693..736
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          737..778
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          876..908
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1000..1032
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1041..1081
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1082..1123
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1124..1165
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   1249 AA;  141586 MW;  32C5D517BB689211 CRC64;
     MDAKSRNYLL RNRQALEKDI KTSYIMDRMI SDEVLTLQEE EKVKQQNTQK ERAAMLINII
     LTKDNNSYRS FYNALLHEGY RDLAALLQDG IPAISSGNGK SSMDGMTSYV KTILCEGGVP
     QRPVVFVTRP KLVDAIKQKL CCLGSDPGWV TVYGMAGCGK TVLTAEALRD HQLLEDYFPG
     GVHWISVGKQ DKAGLLIKLQ NLCSRLEHDS TLSQRPPLNI EEAKDRLRLL MLRKYPRSLL
     ILDDIWDSWV LKAFDNQCQV LITSRDRSVT DAVAGNKYEV HVESGLAHEK GLEILSLFVN
     MKISELPEQA NCLVRECKGS PLVISLIGAL LRDFPSRWEY YLKQLQHKQF KRIRKSSSYD
     YEALDEAMSI SVEQLNDNYK DYYKDLSILP KDVKVPTKVL CILWDMETEE VEDILQEFVN
     KSLLFCDRNG KSFHYYLHDL QLDFLTEKNR NQLQELHKNI VNQYKKYYKL NTPVPSQEDC
     MYWYNFLAYH MAGANMQKEL HDLMFSLDWI KAKTELVGPA HLIHEYVEYS SILDQKDSTV
     RENFQEFLSL NGHLLGRQPF PDIVQLGLCQ PETSILNNKN ALGNPTHLKL TVLPCRNKKS
     LKNLYRLVVR PHRDAVYHAC FSKDRQRIAS CGADKTLQVF KAESGERLLE ISAHDDEILC
     CAFSADGEFV ATCSADKKVK IWNSRTGQCK CVYEEHAEQV NCCQFNNGTG QYLLATCSND
     TFIKLWDLNK KYCRNTMIGH VNSVIHCRFS PNDEYVASCS ADGTVKLWEA RSANELKSIE
     IKDFFRNADE QPDDVEVLVK CCSWSRNGDM LLVVAKNKLL LFDVKTCDLL TQVIVSHHST
     IQYCDFCPGD ELVAVALSHC SVELWNIKSL SKVAYCRGHM SWVHCVTFSP DGSLFLTSSD
     DQTIRIWETK KVCKSSDAVL KSELDVVFHS DEVMILAIYN QKHLQLINGN TDSVVMHTAA
     QESPISCCCL SEDLKFAAFG QESGTIKVLQ LLDGKVLKSR EAYRTSVQHC RFTSDCQTLI
     SSAHDSVIQV WNWQLSECVF LRGHKEAIKD FRLLENSKLL SWSFDGTVKV WNITTGNTEK
     DFACHGGAVL SCAVSPDGSK FSSTSADKTA KIWSFESSSV LHELKGHEAC VRCCTFSPNN
     KLLATGDDKG EIRIWDILTG ALLHFCSPVT VDEGEPTHGG WVTDLSFSPD SKMLVSSGGY
     LKWWNVITGE SLQTFYTNGT NLKSIHVCPN FEVYVTVDNL GILYVLQKL
//
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