ID A0A0A0AB55_CHAVO Unreviewed; 741 AA.
AC A0A0A0AB55;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000256|ARBA:ARBA00040299};
DE EC=2.1.1.366 {ECO:0000256|ARBA:ARBA00039052};
DE AltName: Full=SET domain bifurcated 2 {ECO:0000256|ARBA:ARBA00042995};
DE Flags: Fragment;
GN ORFNames=N301_06551 {ECO:0000313|EMBL:KGL91147.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL91147.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL91147.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL91147.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CC methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]
CC + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA-
CC COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC ChEBI:CHEBI:61976; EC=2.1.1.366;
CC Evidence={ECO:0000256|ARBA:ARBA00036635};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KL871174; KGL91147.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0AB55; -.
DR STRING; 50402.A0A0A0AB55; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01395; HMT_MBD; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Methyltransferase {ECO:0000313|EMBL:KGL91147.1};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW Transferase {ECO:0000313|EMBL:KGL91147.1}.
FT DOMAIN 148..220
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 282..356
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 359..716
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 537..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL91147.1"
FT NON_TER 741
FT /evidence="ECO:0000313|EMBL:KGL91147.1"
SQ SEQUENCE 741 AA; 83597 MW; 4E0573FD61E94049 CRC64;
DLKTFWTQLG GRRVDVIFEQ VQNVLLLLKQ KIKNGTATNQ EYWQAWTLVN EANLGDLLTN
VSDVFDGDGI QETKPKLQHL LTDDNTAESV EASHSFFFSF VPNSKKEEME KTGSGIKEAS
RKIQELPLNL QYQNHKCSSA CLANRAADSF KGENPLKIPI LFHFERRHAK ADCLSKSLDV
NYKAPCGRSL RSFQDVQNYL FETECNFLFV DHFSFNTYVL LGRNTVNPEP LVFDFDISNG
AESVPISFCN DLDRARLPYF KYRRASWPRG YYLNNFSSTF VDSCDCTDGC IDRSKCACLQ
LTARGCSKIS LSPSSKTCHG YSYKRLEGPV PSGIYECSVL CRCDKMMCQN RVVQHGIQVR
LQVFNTEKKG WGVRCLDDID KGTFVCTYSG RLMSRAEARV LGDAGQKLKE KSPVNDRGHG
FFFKKRKFDT DCLDSVTELV QAGKNDILEK RESLPQAVDN ENKSTLVHPK NLSIATAKSP
RTRIAVFHND QLKMVIIIRG FNKLILHFAY SNNTSQPFHY LLFCLKEIDT LVHSASSDED
NSSQIHQSSK TKLTSGTKKR KEKSTQQQKE EHPMEVGQTE SADVDSAECK RKTPSLQGVD
CGSSGVLDDR CVVTPSKNVA LKADCKEENH RKSKRGTSCE DADGDRMLLK NANEENTYVL
DATKEGNVGR FLNHSCCPNL FAQSVFVETH NRSFPWVAFF TNRHVKAGTE LTWDYGYEAG
SMPEAEISCQ CGVQKCRKKT L
//
