ID A0A0A0ANE9_CHAVO Unreviewed; 1985 AA.
AC A0A0A0ANE9;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE Flags: Fragment;
GN ORFNames=N301_12963 {ECO:0000313|EMBL:KGL95536.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL95536.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL95536.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL95536.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KL872436; KGL95536.1; -; Genomic_DNA.
DR STRING; 50402.A0A0A0ANE9; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:KGL95536.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 113..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 222..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 245..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 380..408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 710..728
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 740..763
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 775..799
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 820..853
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 908..933
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1204..1222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1243..1259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1271..1291
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1335..1355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1445..1468
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1527..1545
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1557..1579
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1591..1610
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1658..1680
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1747..1770
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 124..414
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 500..659
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 709..939
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 947..1198
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1202..1477
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1526..1780
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 456..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1960..1985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 405..439
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 474..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1985
FT /evidence="ECO:0000313|EMBL:KGL95536.1"
SQ SEQUENCE 1985 AA; 225665 MW; 2D6F3322285E3D00 CRC64;
MADFLLPPGT NSFHRFTPES LAAIEKRIAE KLARNAKQEY REQLGEEEKP QPQFDLQACK
KLPDIYGTVP PELIGEPLED LDPFYNDRKT FIVLNKGKTI FRFSATPAFL TTYAIFSLIP
LFTLFSMFIM CTILTNCVFM AQSETPSWNK YVEYTFTGIY TFESLIKILA RGFCMTEFTF
LRDPWNWLDF SVIVMAYVGE FVNVGSVSPL RTFRVLRALK TISVIPGLKT IVGALIQSVK
KLADVMILTV FCLSVFALIG LQLFMGNLRH KCVRDYTKFN STNGTLYLDG RMWNTSEEFL
SDPVNYFIKN GTEDVLLCGN STDAGTCPEG YICLKAGENP DHGYTSFDTF GWAFLSLFRL
MTQDYWERLY QQTLRSAGKI YMLFFMLVIF LGSFYLVNLI LAVVAMAYEE QNQATIAETE
EKERKFREAM EMLKKEQEAL AAKGIDSMSL SSLEMSPLAS KNAKERRNKR KKKKSIGGEE
YGEDQRNPKC DYDDGQRRMT LLGISYGPSA NLVKRRTSHG SIFSFRLRGR DTGSETDFAD
DEISTAGEYE SHRGSLLIPR SGRRPSVQSQ VSHSSHPPTP NYTQTGKRNS SVDCNGVVSL
IGGGTGALNP DPTSPAGLLL PPVIMEKPGT GDLLLMPHRP SVDHSDEPFQ RQRAVSAVSI
ITSALEELEE SHQKCPPCWN HFAVKFLIWD CCPLWLLIKK FVKFVVMDPF TDLTITLCIV
LNTLFMALEH YKMTKEFDHM LYIGNLVFTG IFTAEMIFKV IALDPYYYFQ QGWNIFDSII
VILSLMELGL SSMGNLSVLR SFRLLRVFKL AKSWPTLNTL IKIIGNSVGA LGNLTLVLAI
IVFIFAVVGM QLFGKSYLDN VKKISTTGNL PRWHMNDFFH SFLIIFRILC GEWIETMWDC
MEVAGQPLCL LVFLLVMVIG NLVVLNLFLA LLLSSFSADN LSAPDEDGEM NNLQLAFARI
NRGLQYMKHT TWDFCCNVLR HPKTTAEKKA MMKLAAQNTG ALNNCVNSLT AAELGKDMEN
HKENHAEDGM NKNGEKHLGI TDNDDFMTNP DLSICVPIAV GESDIEEEDE EQSTFTEMEQ
EKQLQLRGQR CQSPGVRSQN SEICEELSEL HVDKQLKAQP PPPVGQKELD EISLSEGSTV
DLTNPAELLE QIPEFAEELM EPEDCFPEVC VRFFPCCSVD ITKFPGKIWW RLRKTCYRIV
EHNWFETFII FMILLSSGAL AFEDIYLEDR KNIKTMLEYA DKIFTYIFVL EMLLKWVAYG
FKKYFTNAWC WLDFLIVDVS LISLVASTLG YSEMGPIKSL RTLRALRPLR ALSRFEGMRV
VVNALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFGK CINKTEGDMP LDSKIINNMS
DCILYNVSGT FYWTKVKVNF DNVGAGYLAL LQVATFKGWM DIMYAAVDSR ECEEQPEWEC
NLYMYLYFVI FIIFGSFFTL NLFIGVIIDN FNQQKKKISG QDIFMTEEQK KYYNAMKKLG
SKKPQKPIPR PLNKYQGFIF DVVSKQAFDV SIMILICLNM VTMMVETDDQ SQEKVNILHK
INMLFVAIFT GECIIKMLAL RHYYFTNGWN IFDFVVVILS IVGTVLSDII QKYFFSPTLF
RVIRLARIGR ILRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA IFGMANFAYV
KKEYGIDDMF NFQTFANSML CLFQITTSAG WDGLLNPILN TGPPYCDPNL PNANGSKGDC
GSPAVGILFF VTYIIISFLI VVNMYIAIIL ENFSVATEES TEPLSEDDFD MFYEIWEKFD
PEATQFIEYS ALSDFADALS EPLRIAKPNK IKLIAMDLPM VSGDRIHCLD ILFAFTKRVL
GESGEMDALK IQMEEKFMAA NPSKISYEPI TTTLRRKQEE VSAIVIQRAY RRHLFRRSMK
QASYLYRHRT FDGSILEDDA PEKEGLIAFM MNENYGRPID KSETLSSTSF PPSYDSVTRG
TSDNL
//
