ID A0A0A0ARU3_CHAVO Unreviewed; 578 AA.
AC A0A0A0ARU3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG2 {ECO:0000256|ARBA:ARBA00040479};
DE EC=6.2.1.15 {ECO:0000256|ARBA:ARBA00026113};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
DE AltName: Full=Acyl-CoA synthetase bubblegum family member 2 {ECO:0000256|ARBA:ARBA00043192};
DE AltName: Full=Arachidonate--CoA ligase ACSBG2 {ECO:0000256|ARBA:ARBA00042118};
DE Flags: Fragment;
GN ORFNames=N301_14116 {ECO:0000313|EMBL:KGL96587.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL96587.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL96587.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL96587.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA =
CC (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368,
CC ChEBI:CHEBI:456215; EC=6.2.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00024548};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714;
CC Evidence={ECO:0000256|ARBA:ARBA00024548};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP +
CC diphosphate; Xref=Rhea:RHEA:33607, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:30823, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57387, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036043};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33608;
CC Evidence={ECO:0000256|ARBA:ARBA00036043};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-
CC octadecadienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:33651,
CC ChEBI:CHEBI:30245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57383, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00035848};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33652;
CC Evidence={ECO:0000256|ARBA:ARBA00035848};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-
CC CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00024497};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752;
CC Evidence={ECO:0000256|ARBA:ARBA00024497};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC Bubblegum subfamily. {ECO:0000256|ARBA:ARBA00038034}.
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DR EMBL; KL872704; KGL96587.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0ARU3; -.
DR STRING; 50402.A0A0A0ARU3; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05933; ACSBG_like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43272:SF101; LONG-CHAIN-FATTY-ACID--COA LIGASE ACSBG2; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KGL96587.1};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858}.
FT DOMAIN 4..384
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL96587.1"
FT NON_TER 578
FT /evidence="ECO:0000313|EMBL:KGL96587.1"
SQ SEQUENCE 578 AA; 63718 MW; 35A3F87015B462B0 CRC64;
SCLQLGLERF HGVCILGFNS AEWFIADIGA ILAGGFAVGI YTTNSPEACH YVAENCSANV
VVVENHKQLQ KILEIQHKLP HLKAIIQYGE ELKEKRPNLY SWSEFMDLGK DVPDAQLREI
IESQKPNQCC TLIYTSGTTG QPKGVMLSHD NLTWTAAAAG RFIMLTDATE KQELVVSYLP
LSHIAAQMSD IWSAMTFGVQ VFFAQPDALK GTLVDTLREV RPTAFLGVPR VWEKMEEKMK
SIGAKSSALR RKVASWAKGV GLQTNLKRMN RYSEVPVNFR LARHLVYKKV RKAIGLDRCT
KCYTGAAPIT RETLEFFLSL NIPVLELYGM SESSGPHTIS LPHAFKLTSC GKEVTGCRTL
IHKPDGDGNG EICFSGRHIF MGYLNMEEKT KEAIDEDGWL HSGDLGKHDK DGFLYITGRI
KELIITAGGE NVPPVPIEDA VKDAVPIISN AMLVGDKAKF LAMLLTLKCN TDTETGEPGD
ELTPEAVEYC QKLGSKATKV SEIISSKDKA IYAAIQKGIS AVNEGAVSNA QKVQKWVLLE
KDFSLFGGEL GPTMKLKRSV VAQKYKDQIA QFYADADT
//
