ID A0A0A0AT40_CHAVO Unreviewed; 617 AA.
AC A0A0A0AT40;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=phosphatidylinositol-3-phosphatase {ECO:0000256|ARBA:ARBA00013038};
DE EC=3.1.3.64 {ECO:0000256|ARBA:ARBA00013038};
DE AltName: Full=Phosphatidylinositol-3-phosphate phosphatase {ECO:0000256|ARBA:ARBA00031219};
DE Flags: Fragment;
GN ORFNames=N301_06858 {ECO:0000313|EMBL:KGL97749.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL97749.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL97749.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL97749.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; KL873110; KGL97749.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0AT40; -.
DR STRING; 50402.A0A0A0AT40; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd13343; PH-GRAM_MTMR6; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035998; MTMR6_PH-GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF34; MYOTUBULARIN-RELATED PROTEIN 6; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858}.
FT DOMAIN 117..495
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT COILED 505..539
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 331
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 268..269
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 331..337
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL97749.1"
FT NON_TER 617
FT /evidence="ECO:0000313|EMBL:KGL97749.1"
SQ SEQUENCE 617 AA; 70878 MW; 9B117ACEBC4B199F CRC64;
QVEQVKLLDR FSTSNKSLTG TLYLTATHLL FIDSSQRETW ILHHHIAAVE KLPLTTSGCP
LVIQCKNFRI VHFVVPRERD CHDIYNSLLQ LSRTANYEEL YAFSYNPKQN ESEQVKGWQL
IDLAEEYKRM GVPNANWQLS DANRDYKASI CETYPRELYV PRTASKPIIV GSSKFRSKGR
FPVLSYYHKN KEAAICRCSQ PLSGFSARCL EDEHMLQAIS KANPSNRYMY VMDTRPKLNA
MANRAAGKGY ENEDNYSNIR FQFVGIENIH VMRSSLQKLL EVSGTKGLSV NDFLSGLENS
GWLRHIKAVL DAAVFLVKAI AVESASVLVH CSDGWDRTSQ VCSLGALLLD SYYRTIKGFM
VLIEKDWISF GHKFSDRCGQ LDGDPKEISP VFTQFLESVW NLTEQFPQAF EYNEAFLLQI
HEHVHSCQFG NFLGNCQKER EELKLKEKTY SLWPFLLDEQ KKYQNPLYNP DFSPGLTLLE
PNTVSFNFKF WRNMYHQFDR SMHPRQSVFN LIMNMSEQNK QLEEEIKELE AKIKRKNGQS
DGVLVKEHQQ SAHPAPPALK TPPCYKKEQP LIPVNDAVRT IEGSNTADNR YSEFVEEFSK
AEPAVVSLEY GVARMTC
//
