ID   A0A0A0ATN4_CHAVO        Unreviewed;       678 AA.
AC   A0A0A0ATN4;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
DE   Flags: Fragment;
GN   ORFNames=N301_01603 {ECO:0000313|EMBL:KGL96888.1};
OS   Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX   NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL96888.1, ECO:0000313|Proteomes:UP000053858};
RN   [1] {ECO:0000313|EMBL:KGL96888.1, ECO:0000313|Proteomes:UP000053858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL96888.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
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DR   EMBL; KL872848; KGL96888.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A0ATN4; -.
DR   STRING; 50402.A0A0A0ATN4; -.
DR   Proteomes; UP000053858; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   CDD; cd03881; M28_Nicastrin; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        639..659
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          21..194
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KGL96888.1"
FT   NON_TER         678
FT                   /evidence="ECO:0000313|EMBL:KGL96888.1"
SQ   SEQUENCE   678 AA;  75626 MW;  E63F3A25AAE9CC39 CRC64;
     GCCQGNSVER KIYIPLNKTA PCVRLLNATH QIGCQSSISG DTGVIHVVEK EEDLNWVLAD
     GPHPPYMILL DGNLFNRKVM LQLKGTSRVS GLAVAIAKPS PPQGFSPGLK CPNDGFGVYS
     KDYGPQFAHC NKTVWNPVGS GLSYEDFDFP IFLLEDANET QVIKQCYQDH NVPHDGSVPE
     YPLCAMQLFS HMHAVTSTVT CMRRSSLQST FSINPEIVCD PLLDYNVWST LQPINSSGKV
     DPEKEVIIVA TRIDSHSFFW NIAPGAESAV SSFVTHLAAA EALHKASDIH LLQRNIMFTF
     FQGETFDYIG SSRMVYDMEK DKFPLRLDNI HSFVELNQVA LRNDSILWMH TDPVSRMNES
     VEVQVRNLLD ILSSSSMGAN VTLQEAGYSQ PLPPSSFQRF LRARHIPGVV LTDHKTAFQN
     RYYQSLYDTP ENIRMQYPEG LSPEETLEYV TDTAKSLAEV ATVVARALYR LAGGANNTSA
     IQADPKTVSR MLYGFLIKMN NSWFQSIIKP DIKGILGDVP QHYVAVSSPV NTTYLVQYVL
     ANLTGAVVNL TKEECLNPEK TPSSEKEMYE YAWVQGSLDP NSTSRVPYCV RSTVHLSKAL
     SPAFELRQWG STEYSTWTES RWKEIRARIF LVASRELEII TLVVGIAILI FSLLATYFIN
     AKADVLFSIP RDPGAVAY
//