ID A0A0A0AWJ8_CHAVO Unreviewed; 548 AA.
AC A0A0A0AWJ8;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
DE Flags: Fragment;
GN ORFNames=N301_05866 {ECO:0000313|EMBL:KGL98919.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL98919.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL98919.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL98919.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
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DR EMBL; KL873486; KGL98919.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0AWJ8; -.
DR STRING; 50402.A0A0A0AWJ8; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR Pfam; PF21174; Glce_b_sandwich; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053858}.
FT DOMAIN 347..538
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KGL98919.1"
FT NON_TER 548
FT /evidence="ECO:0000313|EMBL:KGL98919.1"
SQ SEQUENCE 548 AA; 62157 MW; CA3A2DFC1237A1A0 CRC64;
QQSEEASPQE QQRAPPVAGG FNGNKAPGLK YEEIDCLIND EHTVKGRREG NEVFLPFSWV
EKYFEVYGKI AQYDGYDRFE FSHSYSKVYT QRAPYHPDGV FMSFEGYNVE VRDRVKCISG
VEGVPLSTQW GPQGYFYPIQ IAQYGLSHYS KNLTEKPPHI EVYETAEEKD KTGRSADWTV
PKGCSLSTVS DKAKFTSVKQ LFFVCFAENT EGVSLQLGNT RDFIISFDLK FVTNGSVSVV
LETTEKNQLF TVHYVSNTQL IAFKDRDIYY GIGPRTSWST LTRDLVTDLR KGVGLSNTKA
VKQTKIMPKR VVRLVAKGRG FLDNVTISAT AHMAAFFAAS NWLVRNQDER GGWPIMVTRK
LGEGFKSLDP GWYSAMAQGQ AISTLVRAYL LTKDHVFLSS ALRATAPYKL PSEQRGVKAV
FMNRHDWYEE YPTSPSSFVL NGFMYSLIGL YDLKETAGEK LGKEARVLYE RGMESLKAML
PLYDTGSGTI YDLRHFMLGT APNLARWDYH TTHINQLQLL STIDESPIFK EFVKRWKSYL
RGGRAKHN
//