ID A0A0A0AWZ6_CHAVO Unreviewed; 1354 AA.
AC A0A0A0AWZ6;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Regulator of G-protein signaling 12 {ECO:0000313|EMBL:KGL97665.1};
DE Flags: Fragment;
GN ORFNames=N301_16024 {ECO:0000313|EMBL:KGL97665.1};
OS Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius.
OX NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL97665.1, ECO:0000313|Proteomes:UP000053858};
RN [1] {ECO:0000313|EMBL:KGL97665.1, ECO:0000313|Proteomes:UP000053858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL97665.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KL873024; KGL97665.1; -; Genomic_DNA.
DR STRING; 50402.A0A0A0AWZ6; -.
DR Proteomes; UP000053858; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13162; PTB_RGS12; 1.
DR CDD; cd17136; RBD1_RGS12; 1.
DR CDD; cd17138; RBD2_RGS12; 1.
DR CDD; cd08742; RGS_RGS12; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037880; RGS12_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF16613; RGS12_us1; 1.
DR Pfam; PF16611; RGS12_us2; 1.
DR Pfam; PF16612; RGS12_usC; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 22..99
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 226..338
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 708..825
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 957..1027
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1029..1099
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 606..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1213..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1244..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1354
FT /evidence="ECO:0000313|EMBL:KGL97665.1"
SQ SEQUENCE 1354 AA; 149493 MW; 706F23BE9041DFC9 CRC64;
MYRPGETVKR RLNVHAPPRI RSVEVARGRA GYGFTLSGQA PCVLSCVMKG SPADYVGLKA
GDQIFAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGIS HRDSCSSDEE VSFYDGKGWL
KPKPDSKALG INRAEKVVEE MQSGGIFNMI FENPVLCAGN SDNSAPKQRS FSDSAAIKFE
TGNEGVSNPS LLSKEEISKV LNDDSVFRIG LESAEDFGLD ASILNVAMIV GYLGSIELPS
TTSNLENESL QAIRGCMRRL RAEQKIHSLV MMKIMHDCIQ LCSDKSGVVA EYPAEKLAFS
AVCPDDRRFF GLVTMQTNDD ASLAQEDEGV LRTSCHVFMV DPELFHHKIH QGIARRFGLE
CTADPDTNGC LEFPTSSLPV LQFISVLYRD MGELIEGMRA RAFLDGDADA HQNNSTSSNS
DSGIGNFNQE EKNNRVLVVD LGSNPSKHIP NSVWENPVGR GQNQPASHWN GFCHEQEGNI
PLEVIQNDKS QNVSKHLSPS ARIEVPLVSS RNSVPPSKKN AAGIGNQRWL PVHVLQEWQH
GNASDQESYT DSTDGWSSVN CGTLPPPMNK IPADRYRVDG SFGQPQLKSH KNEWSKKMFC
MQNKFGPPHS IRKSKEDKKG AKFGHPMGLN QAPPPRSAVR RSFGRSKRFS ITRSLDDLES
ATVSDGELNS TDLKDCISEN SLSSNASLPS VQSCRRLRER RVASWAVSFE RLLQDPVGVK
YFSEFLRKEF SEENILFWQA CEYFNHVPAH DKKELSYRAR EIFSKFLCSK ATTPVNIDSQ
AQLADDILNS PHPDMFKEQQ LQIFNLMKFD SYTRFLKSPL YQECILAEVE GRPLPDPQRV
PSSPTSKHSI SSEKSNISTP KKLSGKSKSG RSLNEESGEE DTEKKKRGTF FSWSRSKSLG
KSQKRKENGD YPNDSIQSNG LSYRRESQGS MSSTASLDLS EASRLPAFVP DKEKSPKYCC
INLPDGSSSK MAVKSGFSIK EVLSGLCEKH GINIAAVDLF LVGGDKPLVL HQDSSILESR
DLRLEKRTLF RLDLVPINRS VGLKAKPTKP VTEVLRPVVA KYGLNLNELV ARLNGEQEPL
DLGVPISNLD GQRVVLDEKE PTKGRVFADK QKGASVKQSA TVTTSRNQVS TGEGRTLGKS
NSIKMKGENG KNAREVRLSK REDSIAKIGK KKCQKINLDE AEEFFELISK AQSNRADDQR
GLLRKEDLIL PDFLRLPPTG PEPSSSTPTG PKGLNKRISK NDGKDGCTSP NGKQESVQNF
NENSVKKMGY SENKHKSALT ALHSQKTFSV PFNTALSPIP HAQENNAAIW KRQSRELQAE
GIQMVDDENV ADLTLVAEGD ISSPNSTLLP PPPP
//
