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Database: UniProt
Entry: A0A0A0B1T1_CHAVO
LinkDB: A0A0A0B1T1_CHAVO
Original site: A0A0A0B1T1_CHAVO 
ID   A0A0A0B1T1_CHAVO        Unreviewed;      1365 AA.
AC   A0A0A0B1T1;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   05-JUN-2019, entry version 31.
DE   SubName: Full=Vascular endothelial growth factor receptor 3 {ECO:0000313|EMBL:KGL99305.1};
DE   Flags: Fragment;
GN   ORFNames=N301_12173 {ECO:0000313|EMBL:KGL99305.1};
OS   Charadrius vociferus (Killdeer) (Aegialitis vocifera).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae;
OC   Charadrius.
OX   NCBI_TaxID=50402 {ECO:0000313|EMBL:KGL99305.1, ECO:0000313|Proteomes:UP000053858};
RN   [1] {ECO:0000313|EMBL:KGL99305.1, ECO:0000313|Proteomes:UP000053858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N301 {ECO:0000313|EMBL:KGL99305.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|RuleBase:RU000311,
CC         ECO:0000256|SAAS:SAAS01176171};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000311};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU000311}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. CSF-1/PDGF receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000311}.
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DR   EMBL; KL873577; KGL99305.1; -; Genomic_DNA.
DR   Proteomes; UP000053858; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 7.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR   InterPro; IPR041348; VEGFR-2_TMD.
DR   InterPro; IPR009137; VEGFR3_rcpt.
DR   PANTHER; PTHR24416:SF49; PTHR24416:SF49; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF17988; VEGFR-2_TMD; 1.
DR   SMART; SM00409; IG; 6.
DR   SMART; SM00408; IGc2; 4.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 6.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 5.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00600564};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053858};
KW   Immunoglobulin domain {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000256|SAAS:SAAS00598388};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00600689};
KW   Receptor {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00600436, ECO:0000313|EMBL:KGL99305.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053858};
KW   Transferase {ECO:0000256|SAAS:SAAS00602511};
KW   Transmembrane {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00600943, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00293420}.
FT   TRANSMEM    775    799       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      242    323       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      328    411       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      418    552       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      555    670       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      677    763       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      844   1171       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION     1182   1210       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0A0B1T1}.
FT   REGION     1284   1365       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0A0B1T1}.
FT   COMPBIAS   1182   1207       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A0A0B1T1}.
FT   COMPBIAS   1319   1333       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A0A0B1T1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KGL99305.1}.
FT   NON_TER    1365   1365       {ECO:0000313|EMBL:KGL99305.1}.
SQ   SEQUENCE   1365 AA;  154669 MW;  69271FE5D27E43BA CRC64;
     LSFLSTDLVS SYSMTPPTLS ITEEEHVINA KDTLTITCRG QHPLEWSWPG GKVDPAGKEK
     ETELVASAAP SSGRAIREDD CEGTGTKPYC KVLVLTETQA NDTGYYRCYY KYIDAKIEGT
     TAVSAYVFVR DFEQPFINKP ETLLISKKEN TWVPCLVSIP DLNVTLILQN SLIHPDGKST
     FWDNKKGVQV PTHLIRDSLF VQCETVINKK VFKSNFFIIH IAGSELYDIQ LYPKKAMELL
     VGEKLVLNCT VWAEFNSGVR FQWTYPGKQM QRAVMEPERR SLQTHTELSS ILTLHNVSQQ
     DLGKYTCTAT NGAQMLEEST DVIVHEKPFI NVEWRKGPVI EATAGDEAVK LPVKVVAYPP
     PDFQWYKDGK LIPKQSQSSM QIKDVSEQHA GTYTLVLRNR LAGLEKRISL QLIVNVPPRI
     HEKEASSPSI YSRRSPQALT CTVYGIPAPE VIQWQWRPWM PCRMFSRRSL RHRASRRHQR
     DRMPECKDWK DVSQQDAVNP IESIDTWVEF VEGRNKTVSK LAIQEANVSV MYKCIASNKV
     GRDERLIYFY VTTIPDGFEI ESQPSEEPIE GQDLQLSCNA DNYTYENLQW YRLNLSKLHD
     EEGNPLVLDC KNVHHYATKM QGDLRFQPDS NDATLLLTIP NISLGEEGDY VCEVQNRKTR
     EKHCHKKYIS VQALEIPRLK QNLTDIWVNI SDSIEMRCKV DGNHVPEISW YKDEKLVEEV
     SGIDLADFNQ RLSIQRVREE DAGLYLCSVC NAKGCVNSSA SVSVEGSDDR TNVEIVILIG
     TGVIAVFFWI LLILIFCNIK RPAHADIKTG YLSIIMDPGE VPLEEQCEYL PYDSSKWEFP
     RDRLRLGKVL GHGAFGKVVE ASAFGINKSN SCETVAVKML KEGATASEHK ALMSELKILI
     HIGNHLNVVN LLGACTKPNG PLMVIVEFCK YGNLSNYLRT KREGFSPYRE KSPRLRIQVQ
     SIVEAVRADR RSRSGTSDSA IFNRFLMHKS QTAQPIQEVD DLWQSPLTME DLICYSFQVA
     RGMEFLASRK CIHRDLAARN ILLSENNVVK ICDFGLARDI YKDPDYVRKG SARLPLKWMA
     PESIFDKVYT TQSDVWSFGV LLWEIFSLGA SPYPGVQINE EFCQRLKDGT RMRAPEYATA
     EIYRIMLSCW HSDPKERPTF SDLVEILGNL LQENVQQEGK DYIPLNDSHS SEDDGFSQVP
     SSAQQNSDEE DFDMRIRCHS LAARYYNCVS FPGCLTGGNQ IRCPSRIKTF EEFPMTHTMY
     KAHPDNQTDS GMVLASEEFE RIENRHRKEG GFSSKGPSRT AELPGEQSDL RGRCRPSYGS
     QVGGQTFYNS EYGELSEHSE DGSCTPPGGG ASPPTLHASF FSEQY
//
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