ID   A0A0A0B796_9CELL        Unreviewed;       823 AA.
AC   A0A0A0B796;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=Q760_03770 {ECO:0000313|EMBL:KGM01111.1};
OS   Cellulomonas cellasea DSM 20118.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Cellulomonadaceae;
OC   Cellulomonas.
OX   NCBI_TaxID=1408250 {ECO:0000313|EMBL:KGM01111.1, ECO:0000313|Proteomes:UP000029833};
RN   [1] {ECO:0000313|EMBL:KGM01111.1, ECO:0000313|Proteomes:UP000029833}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20118 {ECO:0000313|EMBL:KGM01111.1,
RC   ECO:0000313|Proteomes:UP000029833};
RA   Wang G., Zhuang W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGM01111.1}.
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DR   EMBL; AXNT01000132; KGM01111.1; -; Genomic_DNA.
DR   RefSeq; WP_034633600.1; NZ_AXNT01000132.1.
DR   AlphaFoldDB; A0A0A0B796; -.
DR   STRING; 1408250.Q760_03770; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000029833; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KGM01111.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029833};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          22..475
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   COILED          447..474
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   823 AA;  88003 MW;  D190386BE7A01C70 CRC64;
     MARRNATPDV PAEDVVERIV DIDVATEMEG SFLEYAYSVI YSRALPDARD GLKPVQRRIL
     YQMADMGLRP DRPYVKSARV VGEVMGKLHP HGDTAIYDAM VRMAQPFSLR LPLVDGHGNF
     GSLDDGPAAP RYTEARLAPA AAAMTTGLDE DVVDFVPNYD NKLTQPEVLP AAIPNLLVNG
     ASGIAVGMAT NMAPHNLVEV VAAARHLVAH PDATLDDLMR FVPGPDLPSG GKIVGLDGVR
     DAYRTGRGAF RTRATARIEN VTAKRKGIVI TELPYTVGPE KVIEKIKEGV QSKKLSGISN
     AVDLTDRQHG LRLVIEVKTG FNPEAVLEQL YRYTPLEDSY SINNVALVEG QPRTLGLREL
     LQVWVAHRID VVRRRTTFRL ARRRERLHLV EGLLVAILDI DEVIQVIRTS DDSDTARTRL
     RDVFDLSEPQ AEYILELRLR RLTKFSRIEL EKEQEQLQRE IADLETILAD EERLRGVVSE
     EMADVAATYG TPRRTVLLES AGGTSVTGAA AASRSATPLE IEDSPCWALL SATGLLARTT
     GPDAPLRAEA GVRRAKHDVL RGAVATTARA EVGAVTSRGR VVRVSVLHLP SLPPTDGAPT
     LSGGVPLAEV VTLEAGERVV GLTSLAPDAP TLALGTAQGV VKRVSPGDVP GNRDAWEVIA
     LRQLDEVVGC VEVTDADELV LVASDASLLH FAASSVRPQG RSAGGMAGIK LAAGQRVVHF
     GAVRPGVEAA VVTIAGTSTA LPGTQAGSVK TTPFEVYPGK GRATGGVRAH RFLKGEDTLL
     LAWVGPVPPH ATTSAGQPVE LPAVDTRRDG SGVPLAAPVH AIG
//