ID A0A0A0DE35_9STRE Unreviewed; 295 AA.
AC A0A0A0DE35;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN ORFNames=SSIN_1257 {ECO:0000313|EMBL:KGM36956.1};
OS Streptococcus sinensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=176090 {ECO:0000313|EMBL:KGM36956.1, ECO:0000313|Proteomes:UP000030019};
RN [1] {ECO:0000313|EMBL:KGM36956.1, ECO:0000313|Proteomes:UP000030019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HKU4 {ECO:0000313|EMBL:KGM36956.1,
RC ECO:0000313|Proteomes:UP000030019};
RA Teng J.L., Huang Y., Tse H., Lau S.K., Woo P.C.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC {ECO:0000256|RuleBase:RU362028}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|RuleBase:RU362028};
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876, ECO:0000256|RuleBase:RU362028}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGM36956.1}.
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DR EMBL; JPEN01000070; KGM36956.1; -; Genomic_DNA.
DR RefSeq; WP_037616928.1; NZ_JPEN01000070.1.
DR AlphaFoldDB; A0A0A0DE35; -.
DR STRING; 176090.SSIN_1257; -.
DR PATRIC; fig|176090.4.peg.1218; -.
DR eggNOG; COG0564; Bacteria.
DR Proteomes; UP000030019; Unassembled WGS sequence.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR NCBIfam; TIGR00005; rluA_subfam; 1.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF35; PSEUDOURIDINE SYNTHASE; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362028}.
FT DOMAIN 84..236
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT ACT_SITE 131
FT /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ SEQUENCE 295 AA; 33518 MW; 1BB2217F161ECD00 CRC64;
MRFEFIADEH VKVKIFLKKH EISKSLLAKV KFAGGNIFVN DQPQNAIHLL DIGDKVTVDI
PSEKGFETLE AVNRDLSIIY EDEHFLVLDK PAGLASIPSV NHSNTMANFV KAYYIQQHYE
NQQVHIVTRL DRDTSGLMLF AKHGYAHARL DKQLQKKMVE KRYYALIKGS GELEPEGDII
APIGRNPESI ITRCVTKDGK YAHTSYKIVE RFGDVYLVDI RLHTGRTHQI RVHFAHLGFP
LLGDDLYGGT LEAGITRQAL HCHLLNFYNP FSGQQIGRSS PLPEDFKQVI QNLKN
//
