ID A0A0A0HVQ5_PARBD Unreviewed; 1162 AA.
AC A0A0A0HVQ5;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=NFACT RNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PADG_11661 {ECO:0000313|EMBL:KGM92126.1};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:KGM92126.1, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:KGM92126.1, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:KGM92126.1,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; KN275960; KGM92126.1; -; Genomic_DNA.
DR RefSeq; XP_010759892.1; XM_010761590.1.
DR AlphaFoldDB; A0A0A0HVQ5; -.
DR STRING; 502780.A0A0A0HVQ5; -.
DR GeneID; 22587558; -.
DR KEGG; pbn:PADG_11661; -.
DR VEuPathDB; FungiDB:PADG_11661; -.
DR eggNOG; KOG2030; Eukaryota.
DR HOGENOM; CLU_003612_1_1_1; -.
DR InParanoid; A0A0A0HVQ5; -.
DR OMA; MFLEFFA; -.
DR OrthoDB; 129892at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628}.
FT DOMAIN 559..672
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 989..1129
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 177..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..467
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 128547 MW; 8FE0A137F9931AEE CRC64;
MKQRFSSLDV KVISQELSRA LVGLRISNIY DLSSRICLFK LAKPDTRKQL IVDIGFRCHL
TEYSRTTAAA PSPFISRLRK FLKTRRVTAV SQLGTDRIID IALSDGNFHL LLEFYVGGNI
ILTDKDYKIV ALHRIVHGGG EREEVRVGLQ YGITNKQNYN GVPPLSIERL RETLQRAEEA
EGESGAVEGP GSNKRGKKRQ TEALKRAISR GFPEYPALLL DHSFHAAGFD ANLEPKQALE
DSELMKRLML VLTEAENVIA RLSTLEDTPG YIILKGESKT GEAITEADTD SPKPKNMLYH
DFHPFKPKQF ENVPGMTILT FNTFNKAVDE YFSSVESQKL EYRLTEREEI ARRKLEAAQK
DQENRVGALK EVQELHVRKA QAIEANLLRV EEAINAVNGL IAQGMDWVEI ARLIEMEKSR
QNPVAKVIKL PLKLYENTVT LLLGEPTEDE EPADESDEEE EDSESGDEDG GNKVKLERSK
KAQQQLLSID IDLGISPWAN ARQYYEQRKA AAVKEEKTLK STKKAIKSTE KKVTTDLKHA
LKQEKPILRP TRTPFWFEKF MFFVSSDGYL VLGGRDLQQT EILYRRYLKK GDVYVHADVQ
GATPIFVKNK PGTPDAPIPP GTLSQAGNLC VATSSAWDSK AVMGAWWVNA DQVSKTAPSG
EFVGTGGFVI RGEKHQLPPA QLLLGYAVMF QISEDSIKNH TKFRVQDEPS IVEIAKEVQA
NEVLHSKQDS EAPGADGNKE ISLASEEHDS SDEQDEETDN PLLTGMESEP DDSGGNENKG
GDNGEEKLPS DDTDDEKEYN SVVTKETVVL ESGGDEPITQ PEADVSEQQP GITKRQAIKH
LSARERRQLK KGVLIEQTSV RVADAESQSS SPTPSVAPSV TTTTNTNTLN SNIRGKRGKS
KKLATKYQHQ DEEDRELALR LLGSAPKPDK LREAAKNKAE RQAELEAQKQ RRREQHDRAA
QAERERYKAL QQQGGDGGET QFDDTDTAAD LSCLPSLVGT PVVGDEVLAA IPVCAPWAAL
GHYKYRAKLQ PGIVKKGKAV KEILGKWIFD ATATVNAMEK DRRRDMGKLH ADPSTLGDTR
GDKGEDEVLN GEEDKASLKQ LTAMELELVK GWRDAEIVNM IPVGKVKIIS GGGGGGEKLG
KGKSGKVGGG KGDGGRRQGK RK
//
