ID A0A0A0HXV1_PARBD Unreviewed; 762 AA.
AC A0A0A0HXV1;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN ORFNames=PADG_11728 {ECO:0000313|EMBL:KGM92190.1};
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780 {ECO:0000313|EMBL:KGM92190.1, ECO:0000313|Proteomes:UP000001628};
RN [1] {ECO:0000313|EMBL:KGM92190.1, ECO:0000313|Proteomes:UP000001628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18 {ECO:0000313|EMBL:KGM92190.1,
RC ECO:0000313|Proteomes:UP000001628};
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC clathrin to receptors in coated vesicles. Clathrin-associated protein
CC complexes are believed to interact with the cytoplasmic tails of
CC membrane proteins, leading to their selection and concentration.
CC {ECO:0000256|PIRNR:PIRNR002291}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
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DR EMBL; KN275960; KGM92190.1; -; Genomic_DNA.
DR RefSeq; XP_010759956.1; XM_010761654.1.
DR AlphaFoldDB; A0A0A0HXV1; -.
DR STRING; 502780.A0A0A0HXV1; -.
DR GeneID; 22587625; -.
DR KEGG; pbn:PADG_11728; -.
DR VEuPathDB; FungiDB:PADG_11728; -.
DR eggNOG; KOG1061; Eukaryota.
DR HOGENOM; CLU_006320_4_0_1; -.
DR InParanoid; A0A0A0HXV1; -.
DR OMA; NPPEVQW; -.
DR OrthoDB; 648032at2759; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF3; AP COMPLEX SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|PIRNR:PIRNR002291};
KW Reference proteome {ECO:0000313|Proteomes:UP000001628};
KW Transport {ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 16..532
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT REGION 644..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 82567 MW; 2EE2868391E1855D CRC64;
MAVNRIRGAF TAPRKGETFE LRSGLVSQYA WERKESIQKT IMAMTLGKDV SALFPDVLKN
IATSDLDQKK LVYLYLMNYA KSHPDLCILA VNTFVQDSED PNPLIRALAI RTMGCIRVDK
MVDYMEEPLR KTLRDESPYV RKTAAICVAK LFDLNPALCL ENGFLESLQE MIGDPNPMVV
ANSVTALAEI SDTAPETKAL QITPNTLRKM LMALNECTEW GRVSVLSSLA DYRTSDVKEA
ETICERVAPQ FQHINASVVL AAVKVVFLHM KIINPETAQS YLKKMAPPLV TLVSSAPEVQ
YVALRNIDLL LQSKPNILDK ELRVFFCKYN DPPYLKFQKL DIMVRIANER NVDQLLAELK
EYALEVDMDF VRRAVRAIGQ TAIKIEAAAE KCVSTLLDLI NTKVNYVVQE AIVVIKDIFR
KYPGYEGIIP TLCQCIDELD EPNARGSLIW IVGEYAEKIS NAGDILAGFV DGFNEEFTQT
QLQILTAVVK LFLKRPDKAQ GLVQKVLQAA TAENDNPDIR DRAYVYWRLL SNTTDPNAAK
NVVLSEKPPI VTTIQSLSPA LLDQLLTELS TLASVYHKPP EQFVGEGKYG ADAVQKAAIE
EQLQNARENP LAAAAAAAAV SGTAAPAQMQ SNLESLLDID FDGTAPASAQ KEPPSGMSGL
EGLAGTPIRV HSPASGVGPP SSNNLEDLMG VFGSGTNAGA AFGGGAGAGT QNGTGNNADL
LNGFAGLDLT GSASTPTPTA ASGTGTGTAT TTKSNQDLLD LF
//
