ID A0A0A0JR96_9MICO Unreviewed; 538 AA.
AC A0A0A0JR96;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Neutral metalloproteinase {ECO:0000256|RuleBase:RU366073};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU366073};
GN ORFNames=N803_07300 {ECO:0000313|EMBL:KGN38542.1};
OS Knoellia subterranea KCTC 19937.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Knoellia.
OX NCBI_TaxID=1385521 {ECO:0000313|EMBL:KGN38542.1, ECO:0000313|Proteomes:UP000030011};
RN [1] {ECO:0000313|EMBL:KGN38542.1, ECO:0000313|Proteomes:UP000030011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 19937 {ECO:0000313|EMBL:KGN38542.1,
RC ECO:0000313|Proteomes:UP000030011};
RA Zhu W., Wang G.;
RT "The genome sequence of Knoellia subterranea.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Extracellular zinc metalloprotease.
CC {ECO:0000256|RuleBase:RU366073}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU366073};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU366073}.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388, ECO:0000256|RuleBase:RU366073}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGN38542.1}.
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DR EMBL; AVPK01000002; KGN38542.1; -; Genomic_DNA.
DR RefSeq; WP_035902925.1; NZ_AVPK01000002.1.
DR AlphaFoldDB; A0A0A0JR96; -.
DR STRING; 1385521.N803_07300; -.
DR MEROPS; M04.017; -.
DR eggNOG; COG3227; Bacteria.
DR OrthoDB; 291295at2; -.
DR Proteomes; UP000030011; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU366073};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU366073};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU366073};
KW Reference proteome {ECO:0000313|Proteomes:UP000030011};
KW Secreted {ECO:0000256|RuleBase:RU366073};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU366073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU366073}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU366073"
FT CHAIN 20..538
FT /note="Neutral metalloproteinase"
FT /evidence="ECO:0000256|RuleBase:RU366073"
FT /id="PRO_5039744231"
FT DOMAIN 77..114
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 205..361
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 364..537
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT ACT_SITE 354
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 440
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 538 AA; 55710 MW; 3343AA5CFAE8FD64 CRC64;
MRRSLSVLAC LAAGSAAIAT VVPAASARPA DPIGPLRQLD VASVGASAEQ ALRAAPGLLR
LAAGEDLIAS SALGESSGAR HVRMNRTYAG LPVLGGDLVA HLGADGAVDS VSQTLRAPLT
VSTTPKITSA KARQATRPTL PAGVNLDKAA PTLAVDATDG TPRLVWDVRA SGVRENGTPS
RLHTWVDATT GAVVGSADEI HEADGSGSSL YSGTVTIQTT QSGSSYQLKD TTRGNSQVTD
MGNKTDSIFC QILQIGCSAG TLYTDADNVW GTGSNFNRQT AAVDAAYGQA RTWDYFKNAH
GRNGIWNTGQ GSPSRVHYGS NYVNAFWDGK QMTYGDGDGS SFGPLVSLDV AGHEMSHGVI
ENSANLTYSK ESGGLNESTS DIFGTMVEFS ANNPNDPGDY LIGEEFDLAK GLGFRRMDNP
SSDGSSVNCW SSSVANLDVH YSSGVGNHFF YLLAEGSGAK TFGGKAHNST TCNGTTISGI
GRDAAAKIWY RALTVYMTSS TNYSGARAAT VKAAGDLYGA SSTQAAAVAK AWDAVSVK
//