ID A0A0A0JRG6_9MICO Unreviewed; 493 AA.
AC A0A0A0JRG6;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Glutamate--cysteine ligase {ECO:0000313|EMBL:KGN38642.1};
GN ORFNames=N803_07865 {ECO:0000313|EMBL:KGN38642.1};
OS Knoellia subterranea KCTC 19937.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Knoellia.
OX NCBI_TaxID=1385521 {ECO:0000313|EMBL:KGN38642.1, ECO:0000313|Proteomes:UP000030011};
RN [1] {ECO:0000313|EMBL:KGN38642.1, ECO:0000313|Proteomes:UP000030011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 19937 {ECO:0000313|EMBL:KGN38642.1,
RC ECO:0000313|Proteomes:UP000030011};
RA Zhu W., Wang G.;
RT "The genome sequence of Knoellia subterranea.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00029283};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGN38642.1}.
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DR EMBL; AVPK01000002; KGN38642.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0JRG6; -.
DR STRING; 1385521.N803_07865; -.
DR eggNOG; COG2170; Bacteria.
DR OrthoDB; 240589at2; -.
DR Proteomes; UP000030011; Unassembled WGS sequence.
DR GO; GO:0004357; F:glutamate-cysteine ligase activity; IEA:InterPro.
DR GO; GO:0042398; P:cellular modified amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.590.20; -; 1.
DR InterPro; IPR006336; GCS2.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR InterPro; IPR016602; UCP012666.
DR PANTHER; PTHR36510:SF3; CONSERVED PROTEIN; 1.
DR PANTHER; PTHR36510; GLUTAMATE--CYSTEINE LIGASE 2-RELATED; 1.
DR Pfam; PF04107; GCS2; 1.
DR PIRSF; PIRSF012666; UCP012666; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KGN38642.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030011}.
SQ SEQUENCE 493 AA; 55801 MW; 8163F610882438D1 CRC64;
MGAEVSAQSY TREERQRYRE KVRQNLDVFE RMLTQHSFEF ERPMTGLEIE LNLVNGDYDP
HFANAEVLHA IADPGYQTEL AQYNIELNVP PRPLPGDSAL ELERDLRQSL NDADAKAREV
GSRLVTIGIL PTIMPEHYEG EWISDNNRYT ALNDSIFVAR GEDIYLDIHG PYGERVATYC
DSIAPESACT SVQLHLQVAP ADFADHWNAA QALSPVQVAL AANSPFFFGQ RLHAETRIEL
FKQATDTRPI ELKNQGVRPR VFFGERWITS IFDLFEENSL YFPALLAETT DEDPMARLEA
GEAPDLAELR LHNGTVYRWN RPIYDIVNGR PHLRVENRVL PAGPTIADTL ANAAFYYGAI
RKLAGTERPV WTKMSFAACE ENFERAARDG IDARLYWPGF GQVGADELVL RHLLPLAHQG
LEEWGVSQAV RERFLGIIEA RCQAGVNGAT WQTDAVQRFE DKGSDRRTAL HQMLELYAEH
MGTNEPVHTW PLP
//
