ID A0A0A0KAV3_CUCSA Unreviewed; 953 AA.
AC A0A0A0KAV3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=Csa_6G116660 {ECO:0000313|EMBL:KGN46633.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN46633.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN46633.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|ARBA:ARBA00009476, ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; CM002927; KGN46633.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0KAV3; -.
DR STRING; 3659.A0A0A0KAV3; -.
DR EnsemblPlants; KGN46633; KGN46633; Csa_6G116660.
DR Gramene; KGN46633; KGN46633; Csa_6G116660.
DR eggNOG; KOG0475; Eukaryota.
DR OMA; ESPPYFN; -.
DR Proteomes; UP000029981; Chromosome 6.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IBA:GO_Central.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04592; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Chloride channel {ECO:0000256|ARBA:ARBA00023173};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 456..480
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 501..519
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 539..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 576..601
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 621..638
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 645..668
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 688..711
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 718..736
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 816..874
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 95..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..294
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 105368 MW; 84FD597EEAE218E7 CRC64;
MIISIMGAFD SMGLKLNNAP HYPCLSSLPS AFFCSNFSTL NFSSSISGLH DLSIPISNGL
ENCAVGNRSY DSLLGLHFSL RPKRTASCFR PISALPGSGE SESPISVSSN AGFSIKQSEQ
EEYDDDDAEE EEEGEEEEEG EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE
EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE
EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEGIPFGTGS
STIISSCFVG LLTGIGVVLF NNAVHEIRDF SWDGIPNRGA SWLREMPIED IWKRVILVPA
SGGFLVSFLN LLRDATDVKV DQPQGDDPST KFGVPISISN KLKAALQPFL KAIAASVTLG
TGNSLGPEGP SVDIGTSVGK GISTVFEMNS RTKLSLIAAG SAAGISSGFN AAVAGCFFAI
ESVLWPSPAD STFSLTNTTS MVILSAVIAS VVSQVGLGVE PAFKVPVYDF RSPSELPLYL
LLGVLCGLVS LSFSKCTSYL LATVDKFHKE FGAPRAMFPI LGGFTIGLIA LAYPEILYWG
FENVDLLLES RPFVKPLSAE LLAQLVVIKI LATSLCRASG LVGGYYAPSL FIGAATGMAY
GKFIGIALSE PNSVLDFSIF EVASPQAYGL VGMAATLAGV CQVPLTAVLL LFELTQDYRI
VLPLLGAVGV SSWITSGQKR KRSSQQTKKL SPGKSPSTQQ STAYDSNANN QSSNYAEDGQ
TNYPNDLCEI ESSLCAYESD SETVELERKI SVSEAMTTKY ITILMGTCLV EAVNLMLAEK
QSCALIVDEG NILIGILELE DIQKLSKNAK SRNEQLKDFV VSEICSLDEK MCRVPWTATP
SMDILTAKMI MKNLGVTQVP VVRDQMGYVV GVLDWECIDL TCRILATRES LGR
//