ID A0A0A0KNS0_CUCSA Unreviewed; 355 AA.
AC A0A0A0KNS0;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=WAT1-related protein {ECO:0000256|RuleBase:RU363077};
GN ORFNames=Csa_5G506320 {ECO:0000313|EMBL:KGN51273.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN51273.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN51273.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU363077}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU363077}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000256|ARBA:ARBA00007635, ECO:0000256|RuleBase:RU363077}.
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DR EMBL; CM002926; KGN51273.1; -; Genomic_DNA.
DR RefSeq; XP_004151019.1; XM_004150971.2.
DR AlphaFoldDB; A0A0A0KNS0; -.
DR STRING; 3659.A0A0A0KNS0; -.
DR EnsemblPlants; KGN51273; KGN51273; Csa_5G506320.
DR GeneID; 101216519; -.
DR Gramene; KGN51273; KGN51273; Csa_5G506320.
DR KEGG; csv:101216519; -.
DR eggNOG; ENOG502QUF7; Eukaryota.
DR OrthoDB; 5547165at2759; -.
DR Proteomes; UP000029981; Chromosome 5.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; WAT1-RELATED PROTEIN; 1.
DR PANTHER; PTHR31218:SF215; WAT1-RELATED PROTEIN; 1.
DR Pfam; PF00892; EamA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU363077};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW Transmembrane {ECO:0000256|RuleBase:RU363077};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363077}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 47..65
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 109..128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 140..158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 257..276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363077"
FT DOMAIN 26..143
FT /note="EamA"
FT /evidence="ECO:0000259|Pfam:PF00892"
SQ SEQUENCE 355 AA; 39086 MW; EBDF7C94BF55ABFF CRC64;
MKKLSEVWKR EGKAYLGVIA IRTADSGLIV IAKIALNHGM SPQVYSLYRY FVASIVVAPF
CFLSYRKGPR PRMTWCILAK ILLLGTMESV VITNTYFTGL KYVTPTFSTA MSNCIPALSF
FFAWIFGMEK VDIRRFSSQV KIIGTAVTVG GAMIMTFVEG PKFRFPWTNE HNSLHNHSST
PPSNVNNQDS FKGVILVTIA ILGASVSCII QAIVLKSYPL GLVVTFMVCI VGVVEGTVVA
LAKEWNNPPV WSIHFDFQLL AFLYAGIMMS GFSYFIQGVV LEAKGPVFLT IFFPLSTIIV
AIISSFAISE VLSLGKVMGA LVIIIGLYLV LWGKTKDHAI ENKAARPIDD ATPRE
//
