ID A0A0A0KYC3_CUCSA Unreviewed; 894 AA.
AC A0A0A0KYC3;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=[Histone H3]-lysine(27) N-trimethyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Csa_4G003700 {ECO:0000313|EMBL:KGN52856.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN52856.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN52856.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; CM002925; KGN52856.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0KYC3; -.
DR STRING; 3659.A0A0A0KYC3; -.
DR EnsemblPlants; KGN52856; KGN52856; Csa_4G003700.
DR Gramene; KGN52856; KGN52856; Csa_4G003700.
DR eggNOG; KOG1079; Eukaryota.
DR OMA; DMCAGST; -.
DR OrthoDB; 902834at2759; -.
DR Proteomes; UP000029981; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031519; C:PcG protein complex; IEA:EnsemblPlants.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0046976; F:histone H3K27 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0031507; P:heterochromatin formation; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0048587; P:regulation of short-day photoperiodism, flowering; IEA:EnsemblPlants.
DR CDD; cd10519; SET_EZH; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF14; HISTONE-LYSINE N-METHYLTRANSFERASE EZA1; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS51576; SAM_MT43_EZ; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 632..731
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 745..860
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 311..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..67
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 322..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 100203 MW; 43845F784BC34794 CRC64;
MASTNPIHSA DKLTVALGDQ STVIVSLTNR VNTLKRQIQA ERFVLVKEKL ENNAQKLASN
VAQAMSTTSR NALSVVEENR NGKMLLSRME FPLCKLSGIA YGAGDKDYIN NQEVVYSISI
KLPYIEKLPP YTTWIFLDRN QRMAEDQSVV GRRRIYYDQH GSEALICSDS EEELAEPEDE
KHEFSEGEDR VLWIIIQEHG VGENVLQLLS HSIGCTTSEI QERCNVLKER NYRADLSSKV
LEESVFKKGI SLYKSLSSTL DSFDNLFCRR CMVFDCRLHG CSQSLIYPVS KPNNEKQLYW
PEHEEERKPC SNQCILEQTK NKNPEQRNKR PRSSKPEESS VHLESDILED EKSLTGKLSS
STSKGISVSE VTAGMDSDIS MGTATNPGSG AKQKAVEHQI KDSVSNDPEL ISNKFQDCKK
QKMLPAMDVA NASIDSSPEL SKITSIKSSQ EDIHRLQKNE FQKDAITLGE ANEQTKEKTS
PSNIASCNNF PDTARSDTVE ATALSTSKLS TETVSEPVEG TRGNSEWKLM EKELYMKGIE
IFGRNSCLIS RNLLSGLKTC MEVFNYMHNG GASTSHRSSS MPSSNADDIG GADIDYTVLE
QDMRIRSRLL RKRGKARKLK YSWKSAGHPS FWKRIADGKN QSCKQYTPCG CLSSCGKQCP
CLHNGTCCEK YCGCSKSCKN RFRGCHCAKS QCRSRQCPCF AAGRECDPDV CRNCWVSCGD
GSMGEPPRQG DGQCGNMRLL LRQQQRILLG KSDVAGWGAF LKNSVNKNDY LGEYTGELIS
HREADKRGKI YDRANSSFLF DLNDQYVLDA YRKGDKLKFA NHSSNPNCYA KVMLVAGDHR
VGIFAKEHIE ATEELFYDYR YGPDQAPAWA RRPEGSKRDD TSISQGRAKK HQSH
//
