ID A0A0A0L5I8_CUCSA Unreviewed; 1148 AA.
AC A0A0A0L5I8;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Disease resistance protein RGA3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Csa_3G172400 {ECO:0000313|EMBL:KGN57235.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN57235.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN57235.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
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DR EMBL; CM002924; KGN57235.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0L5I8; -.
DR EnsemblPlants; KGN57235; KGN57235; Csa_3G172400.
DR Gramene; KGN57235; KGN57235; Csa_3G172400.
DR eggNOG; KOG4658; Eukaryota.
DR OMA; YNNITHC; -.
DR Proteomes; UP000029981; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981}.
FT DOMAIN 9..97
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 180..416
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1148 AA; 131344 MW; C65C39E34B44BE49 CRC64;
MADFIWTFAL QEILKKTLHL ATQQIRLASG FNHDLSKLLH SLLFFEAILR DVDRTKSDRQ
SVKIWVTKLQ DLVLDAEVVL DELSYEDLRR EVDVNGNSKK RVRDFFSFSN PLMFRLKMAR
KIRTITQVLN EIKGEASAVG VIPKGGNDEI VADNGHIPET DSFLDEFEVV GRRADISRIV
NVVVDNATHE RITVIPIVGM GGLGKTTLAK AVFNHELVIA HFDETIWVCV TATFDEKKIL
RAILESLTNF PSGLDSKDAI LRRLQKELEG KRYFLVLDDV WNENVKLWNN FKSLLLKITN
SIGNRVLVTT RSEEAGKIME TFPSHHVEKL SDDECWSIFK ERASANGLPL TPELEVIKNV
LAEQFGGIPL VAKVLGGAVQ FKKRTETWLM STLETLIMNP LQNENDVSSI LRLSVDHLPN
SSLKQCFAYF SNFPKGFNFE KEQLIQFWMA EGFIQPSDKV NPETMEDIGD KYFNILLARS
LFQDIVKDEN GKITHCKMHH LLHDLAYSVS KCEALGSNLN GLVDDVPQIR QLSLIGCEQN
VTLPPRRSME KLRSLFLDRD VFGHKILDFK RLRVLNMSLC EIQNLPTSIG RLKHLRYLDV
SNNMIKKLPK SIVKLYKLQT LRLGCFRGEA PKKFIKLISL RHFYMNVKRP TTRHMPSYLG
RLVDLQSLPF FVVGTKKGFH IEELGYLRNL RGKLKLYNLE LVRNKEEAMR ADLVKKDKVY
KLKLVWSEKR ENNYNHDISV LEGLQPHINL QYLTVEAFMG ELFPNLTFVE NLVQISLKNC
SRCRRIPTFG HLPNLKVLEI SGLHNLKCIG TEFYGNEYGE GSLFPKLKRF HLSDMNNLGR
WEEAAVPTEV AVFPCLEELK ILDCPRLEIA PDYFSTLRTL EIDDVNNPIS QITLQTFKLL
GIIHSGNLSG LPEELRGNLS SLEEFKVWYY LHLKSFPTIQ WLTDILKGKT GYDTKWTNIQ
SHGLESYTSV NELSIVGHSD LTSTPDIKAL YNLSSLTISG LKKLPKGFHC LTCLKSLSIG
GFMEGFDFRP LLHLKSLENL AMIDFGLAES TLPDELQHLT GLKHLKIVGF QGIESLPEWL
GNLNSLESLH IESCRKLREL PEAMGCLAKL EEVRSFNCPE LRVYQDESEW AKISYIPRFI
SFNYWVDE
//
